Post - Doctoral Researcher

„Knowledge becomes health“ – we are filling this motto with life every day, developing new ideas and improving old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital.

Post – Doctoral Researcher

(We are targeting applicants of all genders)
Full time | limited | Announcement number: 564-2024

The position is to be filled at the Department of Hematology / Oncology of the University Hospital Frankfurt at the earliest possible date.

The Department of Hematology / Oncology offers a broad diagnostic and therapeutic spectrum for patients with solid tumors, as well as malignant diseases of the hematopoietic system.

The research group of Prof. Dr. med. Thomas Oellerich is studying oncogenic signal transduction mechanisms, tumor viability regulators, as well as therapy resistance mechanisms to innovative therapies with a main focus on acute myeloid leukemia and aggressive lymphomas. The post-doctoral research position is funded by the German Cancer Aid (Deutsche Krebshilfe) to elucidate proteogenomic mechanisms of oncogenesis and therapy resistance in acute myeloid leukemia (AML). The project will focus on the functional characterization of oncogenic mechanisms in acute leukemia by application of proteogenomic approaches in order to identify new therapeutic vulnerabilities that can be targeted by innovative drugs.

To answer our scientific questions we are applying the following experimental techniques (among others): Innovative CRISPR-Cas9 screening technologies, quantitative (phospho-)proteomic analyses, NGS, FACS analysis and cell sorting, innovative imaging technologies (e.g. PLAs and high resolution microscopy), mouse experiments.

• Independently design scientific projects, plan, establish, and analyze in vitro as well as in vivo experiments
• Write manuscripts and grants
• Presentation of scientific data at national and international conferences
• Train and instruct scientific employees (technical assistants, MD and PhD doctoral candidates) allocated to the project
• PhD degree in biology, molecular medicine or a related life science, ideally in cancer research
• Fundamental theoretical and practical expertise in molecular biology (e.g. cloning, PCR) and protein biochemical techniques-experimental as well as in cell culture (e.g. production of virus particles for genomic modifications) techniques
• Track record of publications in peer-reviewed journals
• A high level of motivation and interest in answering scientific questions in an interdisciplinary academic cancer research setting
• Flexibility and responsibility, as well as very good communications skills in German or English
• Experience with high-throughput-screening analyses (e.g. RNAseq., NGS) and in vivo mouse experiments (FELASA B or C certificate) is an advantage
• Motivation to learn, apply and establish new techniques, ability to critically analyze and reflect data
• Very good computational skills (PowerPoint, Excel, Word, GraphPad Prism, FlowJo, Adobe Illustrator, data analysis with R or python is an advantage)
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required

Work environment: We offer you an interesting, versatile, and attractive working environment in a highly motivated, international team consisting of MDs and PhDs with background in basic science, cancer biology and translational leukemia / lymphoma research in a lab with modern state-of-the-art infrastructure; access to comprehensive further training program with access to DKTK School of Oncology and Mildred-Scheel Network.

Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes.

Mobility: Free public transport in all Hessen (Free State Ticket Hessen).

Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks.

Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact ), child care during holidays.

Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise.

Professional development: Internal and external training for your professional development.

Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications.

Use the time until August 4, 2024 to apply. Please submit your online application including a possible starting date and your salary expectations. For further information regarding the position and project, please contact Prof. Thomas Oellerich via E-Mail: or Dr. med. Sebastian Wolf via E-Mail:

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