Beamline Scientist for methods development in Macromolecular Crystallography Paul Scherrer Institute

The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation, and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science, and economy. PSI is committed to the training of future generations; therefore, about one quarter of our staff are post-docs, post-graduates, or apprentices. Altogether, PSI employs 2300 people.

The Macromolecular Crystallography MX group at the Swiss Light Source SLS is responsible for developing and operating advanced MX beamlines and a crystallization facility. As part of the SLS 2.0 upgrade, we are enhancing beamline performance and unlocking new opportunities for MX research, providing state-of-the-art tools and expanded capabilities for the scientific community. We are seeking a motivated scientist to drive advancements in dynamic macromolecular crystallography and support cutting-edge research at our beamlines.

Your tasks

• Develop methodologies for dynamic macromolecular crystallography
• Design and maintain online data processing and visualization frameworks for standard MX and dynamic MX at SLS and SwissFEL
• Integrate molecular dynamics simulations and ML-based structure prediction workflows into crystallographic pipelines
• Establish collaborations, engage with the scientific community, and conduct user outreach
• Support academic and industry users

Your profile

• PhD degree in natural science, engineering, or a related field
• Academic or industrial work experience after PhD
• Research experience in macromolecular crystallography, data analysis, and computational methods
• Previous experience in working at or utilizing synchrotron or XFEL facilities
• Excellent collaboration and communication skills
• Good command of English

We offer

Our institution is based on an interdisciplinary, innovative, and dynamic collaboration. You will profit from systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.

This is a Tenure Track position. The employment contract will initially be limited to 3 years.

For further information, please contact Dr. Meitian Wang, e-mail , or Dr. Filip Leonarski, e-mail .

Please submit your application online by 26 January 2025 (including list of publications and addresses of referees) for the position as a Beamline Scientist (index no. 6124-01).

Paul Scherrer Institute, Human Resources Management, Elke Baumann, 5232 Villigen PSI, Switzerland.

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