Finde einen Job 
Finde eine Ausbildung 
Top Arbeitgeber 
Top Universitäten 
Für Unternehmen Auf einen Blick
- Aufgaben: Dive into cutting-edge research on tumor immunology and the tumor macroenvironment.
- Arbeitgeber: Join a dynamic team at UKE, a leader in medical research and innovation.
- Mitarbeitervorteile: Enjoy attractive compensation, extensive training, and a family-friendly work environment.
- Warum dieser Job: Make a real impact in cancer research while collaborating with top scientists.
- Gewünschte Qualifikationen: Must have a degree in relevant fields like biology or immunology; experience with multi-omics is a plus.
- Andere Informationen: Position is temporary for three years, working 65% of regular hours.
Das voraussichtliche Gehalt liegt zwischen 36000 - 60000 € pro Jahr.
Main tasks
Cancer undergoes a complex parasitic evolution, continuously evading immune system detection while orchestrating profound changes in its surrounding microenvironment, referred to as the tumor microenvironment (TME). Beyond intrinsic tumor factors, host-related elements—such as the microbiota, microbiota-derived metabolites, diet, and hormones—collectively known as the macroenvironment, play a pivotal role in shaping the TME and potentially exacerbating cancer progression.
This research project will investigate how the immune system is bidirectionally influenced by both the microenvironment and macroenvironment during carcinogenesis and therapy. By leveraging state-of-the-art multi-omics techniques—including single-cell sequencing, spatial transcriptomics, shotgun metagenomic sequencing, and metabolomic screening—alongside advanced murine cancer models and in vitro systems, we aim to elucidate the intricate interplay between the TME and the macroenvironment in driving cancer progression and therapy resistance. This project builds on previous studies, such as Tintelnot et al., Nature 2023, and Tintelnot et al., Cancer Immunology Research 2024.
We are seeking a motivated and innovative candidate with a passion for science and the curiosity to think creatively and push boundaries. The primary goal of this position is to advance our understanding of the tumor macro- and microenvironment and its influence on the immune system in the context of cancer. Your expertise will be instrumental in uncovering the molecular mechanisms driving cancer progression and therapy resistance, with the ultimate aim of translating these insights into clinical benefits for patients.
This position is temporary for three years in accordance with WissZeitVG and to be filled with 65% of the regular weekly working hours.
Your Profile
- Completed academic studies in chemistry, biology, biochemistry, human biology, physiology, immunology or related subjects
- Profound knowledge in either chemistry (drug design, chemical modification of metabolites), immunology, microbiota, cancer biology or cancer metabolism
- Prior knowledge in bioinformatic analysis of multi-omic data and/or work with laboratory mice is a plus
- High degree of intrinsic motivation
Immunity status
Please note that employment is contingent upon proof of immunization or immunity against the measles virus, in accordance with applicable legal and medical requirements. Documentation (e.g., vaccination certificate) must be provided before employment begins.
Our Offer
- Attractive compensation according to TVöD/VKA
- Secure employment with meaningful work and respectful collaboration
- Comprehensive onboarding and open knowledge exchange within the team
- Extensive training and further education programs at our UKE Academy for Education and Careers
- Opportunities to contribute to our „UKE INside“ personnel policy through cross-professional and cross-hierarchical projects
- Sustainable travel: subsidies for the Deutschlandticket as a job ticket, and Dr. Bike bicycle service
- Family-friendly working environment: cooperation on childcare, free vacation childcare, advice for employees with relatives in need of care
- Excellent health, wellness, and sports programs
- A wide range of dining options in our staff restaurant, with additional choices available at the „Health Kitchen“ cafés, bistros, and an on-site supermarket
- Access to cutting-edge technologies and equipment
- Weekly one-on-one meetings with the PI to ensure guidance and progress
- Access to human material for translational studies and a range of sophisticated mouse models (germ-free mice, cancer models, immune cell reporter mice), as well as advanced multi-omics platforms (single-cell sequencing, metabolomic screening, shotgun metagenomics) and corresponding bioinformatics pipelines
- Daily scientific exchange through lab meetings, topic meetings, and journal clubs
- A strong national and international collaboration network
- A dynamic, interdisciplinary team of scientists from diverse fields including medicine, biology, microbiology, and physiology
#J-18808-Ljbffr
PhD (all genders) in tumor immunology with a specific focus on the tumor macroenvironment Arbeitgeber: Universitätsklinikum Hamburg-Eppendorf
Kontaktperson:
Universitätsklinikum Hamburg-Eppendorf HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: PhD (all genders) in tumor immunology with a specific focus on the tumor macroenvironment
✨Tip Number 1
Familiarize yourself with the latest research in tumor immunology, especially studies like Tintelnot et al. This will not only enhance your understanding but also allow you to engage in meaningful discussions during interviews.
✨Tip Number 2
Highlight any hands-on experience you have with multi-omics techniques or laboratory mice. Being able to discuss specific projects or results can set you apart from other candidates.
✨Tip Number 3
Showcase your intrinsic motivation and passion for science in your conversations. We value candidates who are curious and eager to push boundaries in their research.
✨Tip Number 4
Network with professionals in the field of cancer research. Attend relevant conferences or seminars to meet potential colleagues and learn about current trends, which can be beneficial for your application.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: PhD (all genders) in tumor immunology with a specific focus on the tumor macroenvironment
Tipps für deine Bewerbung 🫡
Understand the Research Focus: Dive deep into the specifics of tumor immunology and the tumor macroenvironment. Familiarize yourself with recent studies, especially those mentioned in the job description, to demonstrate your knowledge and interest in the field.
Highlight Relevant Experience: In your application, emphasize any academic or research experience related to chemistry, biology, immunology, or cancer research. If you have worked with multi-omics techniques or laboratory mice, make sure to detail this experience.
Showcase Your Motivation: Express your intrinsic motivation for scientific research and your curiosity to explore new ideas. This position seeks a candidate who is innovative and eager to push boundaries, so let your passion shine through in your application.
Prepare Documentation: Ensure you have all necessary documentation ready, including proof of immunization against the measles virus, as this is a requirement for employment. Additionally, prepare your CV, cover letter, and any relevant certificates or transcripts.
Wie du dich auf ein Vorstellungsgespräch bei Universitätsklinikum Hamburg-Eppendorf vorbereitest
✨Show Your Passion for Science
Make sure to express your genuine enthusiasm for tumor immunology and the complexities of the tumor microenvironment. Share any relevant experiences or projects that highlight your curiosity and innovative thinking in this field.
✨Demonstrate Your Technical Skills
Be prepared to discuss your knowledge in multi-omics techniques, bioinformatics, and any hands-on experience with laboratory mice. Highlight specific examples where you've applied these skills in previous research or studies.
✨Understand the Research Context
Familiarize yourself with the recent studies mentioned in the job description, such as those by Tintelnot et al. This will show that you are engaged with current research and understand the significance of the work being done in this area.
✨Prepare Questions About the Team and Projects
Think of insightful questions regarding the team dynamics, ongoing projects, and how your role would contribute to the overall goals. This demonstrates your interest in collaboration and your eagerness to integrate into their research environment.
