Contractor for ADME

Contractor for ADME – enzymology and DDI (m/w/d)

Contractor for ADME – enzymology and DDI (f/m/d) – enzyme biochemistry / kinetics assessment / radio-HPLC / data analysis / English

Project:
For our customer a big pharmaceutical company in Basel we are looking for a highly qualified SContractor for ADME – enzymology and DDI (f/m/d).

Background:
Working principally on small molecule projects, we are looking for a motivated candidate to fill the gaps in the ADME field for drug development. A position is available for a 1-year contractor to work on advancing in vitro assay techniques to estimate fractions metabolized by enzymes to support clinical PK prediction and drug-drug interaction (DDI) risk assessment for small molecules portfolios.

The perfect candidate:
This role requires strong communication skills, the ability to work independently in a fast-paced and quickly changing environment in close collaboration with partner functions
The manager is looking for someone who is interested in a hands-on laboratory role

Tasks & Responsibilities:

• Conduct the laboratory-based assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
• Analyzing incubation samples via LC-MS/MS and radio-HPLC, including bioanalytical method development and/or validation.
• Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors.
• Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
• Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation.

Must Haves:

• You have a BSc or MSc degree in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD) (recent PhDs might be taken into consideration if they are aware that this is a purely laboratory position, however candidates with just a BSc/MSc are strongly preferred)
• You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), hands-on/experimental enzyme kinetics assessment and the respective experimental designs.
• Experience in bioanalytical method development/validation for radio-HPLC (e.g. Thermo®) and LC-MS/MS (e.g. Sciex®). This includes troubleshooting and data analysis (e.g.using Analyst® software).
• You have a strong interest in translational approaches leveraging in vitro data and clinical data.
• Fluent English

Nice to have:

• Previous experience working in the pharmaceutical industry, biotech or CRO
• German skills
• Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies) is an advantage.

Reference Nr.: 923218TP
Role: Contractor for ADME – enzymology and DDI (f/m/d)
Industrie: Pharma
Workplace: Basel
Pensum: 80-100%
Start: 01.04.24
Duration: 12++
Deadline :14.02.2024