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- Aufgaben: Dive into macrophage metabolism and its role in obesity-related conditions.
- Arbeitgeber: Join a dynamic research group at TU Braunschweig focused on innovative metabolic studies.
- Mitarbeitervorteile: Gain hands-on experience with cutting-edge methodologies and collaborate with top researchers.
- Warum dieser Job: Make a real impact on obesity research while developing your skills in a supportive environment.
- Gewünschte Qualifikationen: Master's degree in biology, biochemistry, or immunology; strong interest in metabolism and immunology required.
- Andere Informationen: Project starts April 2025; apply by February 28, 2025.
Das voraussichtliche Gehalt liegt zwischen 36000 - 60000 € pro Jahr.
Who are we?
The dynamic young group of Pathometabolism of Myeloid Cells (group leader: Dr. Wei He), located at the Braunschweig Integrated Centre of Systemsbiology (BRICS), investigates cellular metabolism of myeloid cells in the context of tumor development and obesity-associated conditions. In particular, we focus on cellular metabolites associated with pathologic conditions-triggered myeloid cell activation.
Project description
This project is focused on obesity-associated intracellular metabolites in macrophages. In preliminary experiments, we have identified multiple metabolites accumulating in macrophages of obesity-related models in vitro and in vivo. The PhD candidate will investigate the molecular mechanism underlying the accumulation of these metabolites, discover how these metabolites affect macrophage metabolism and functions in the context of obesity, and reveal these metabolites-initiated intercellular crosstalk between macrophages and adipocytes/hepatocytes. Expectedly, this study will provide a vital basis for the development of novel dietary/pharmaceutical interventions in obesity and its associated complications such as insulin resistance, type-2 diabetes, fatty liver, etc. This project is in close collaboration with Prof. Zeinab Abdullah (Institute for Molecular Medicine and Experimental Immunology, Universitätsklinikum Bonn, Bonn). The in vivo part of this project will be performed in her lab.
Methodology
We combine a variety of immunologic, metabolic, and multi-omics methods to understand the phenotypic changes and mechanistic actions in macrophages themselves and crosstalk with adipocytes/hepatocytes, triggered by disease conditions-associated metabolites. Notably, mass spectrometry will be one of the central methodologies – we utilize non-targeted metabolomics to discover potential metabolites, and apply stable isotopomer-assisted flux analysis to uncover specific metabolic pathways. Obesity-associated models will be implemented with in vitro cell-based studies and in vivo mouse studies.
Your profile
- Recently or about to obtain a master\’s degree in biology, biochemistry, immunology, or similar.
- Strong interests in metabolism, immunology, and diseases.
- Working experience in biochemistry, cell biology, and immunology are required. Experience in bioinformatics and animal handling are not required but will be a plus.
- Strong speaking/writing skills in English. Knowledge in German is not required but will be a plus.
Expected project start: April 2025
Interested?
Please send your CV and cover letter including a summary of your master\’s thesis and other lab experiences to Dr. Wei He, before 28th Feb. 2025.
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PhD position – macrophage metabolism in the context of obesity TU Braunschweig Arbeitgeber: Dgmet
Kontaktperson:
Dgmet HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: PhD position – macrophage metabolism in the context of obesity TU Braunschweig
✨Tip Number 1
Make sure to familiarize yourself with the latest research on macrophage metabolism and obesity. This will not only help you understand the project better but also allow you to engage in meaningful discussions during the interview.
✨Tip Number 2
Connect with current or former members of the Pathometabolism of Myeloid Cells group. They can provide insights into the lab culture and expectations, which can be invaluable for your application and interview preparation.
✨Tip Number 3
Highlight any relevant laboratory techniques you have experience with, especially those related to biochemistry and immunology. Being able to discuss your hands-on skills confidently can set you apart from other candidates.
✨Tip Number 4
Prepare to discuss your master's thesis in detail, particularly how it relates to the project at hand. This shows your ability to connect your past work with the goals of the PhD position, making you a more compelling candidate.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: PhD position – macrophage metabolism in the context of obesity TU Braunschweig
Tipps für deine Bewerbung 🫡
Understand the Project: Make sure to thoroughly read the project description. Familiarize yourself with the focus on macrophage metabolism and obesity, as well as the methodologies mentioned, such as mass spectrometry and metabolomics.
Tailor Your CV: Highlight your relevant academic background, especially your master's degree in biology, biochemistry, or immunology. Include any specific experiences related to metabolism, immunology, and diseases that align with the project's goals.
Craft a Compelling Cover Letter: In your cover letter, express your strong interest in the research area. Summarize your master's thesis and lab experiences, emphasizing how they relate to the project. Make sure to convey your enthusiasm for contributing to the team's research.
Proofread Your Application: Before submitting, carefully proofread your CV and cover letter. Ensure there are no grammatical errors and that all information is clear and concise. A polished application reflects your attention to detail and professionalism.
Wie du dich auf ein Vorstellungsgespräch bei Dgmet vorbereitest
✨Know Your Research
Make sure to familiarize yourself with the latest research on macrophage metabolism and obesity. Be prepared to discuss how your background aligns with the project goals and any relevant findings from your master's thesis.
✨Highlight Relevant Experience
Emphasize your working experience in biochemistry, cell biology, and immunology during the interview. If you have any experience with mass spectrometry or metabolomics, be sure to mention it as it directly relates to the methodologies used in this project.
✨Prepare Questions
Think of insightful questions to ask Dr. Wei He about the project and the lab's research focus. This shows your genuine interest and helps you understand how you can contribute to the team.
✨Showcase Communication Skills
Since strong speaking and writing skills in English are required, practice articulating your thoughts clearly and concisely. You might also want to prepare a brief summary of your master's thesis to present during the interview.
