PhD Position (m/f/d) in T-Cell Immunology

PhD Position (m/f/d) in T-Cell Immunology

The research group of Prof. Marc Schmidt-Supprian at the Institute of Experimental Hematology at the Technical University Munich is seeking a highly motivated PhD student to join our team starting from now onwards. The research project focuses on regulatory T (Treg) cells and investigating their context-specific identity and function in health and B cell-driven autoimmune diseases. This collaborative project is embedded in the Transregional Collaborative Research Centre TRR 355 and aims at integrating the function of regulatory T cells in mice and men and the position is funded for three years.

Project Overview:

The candidate will contribute to a collaborative DFG-funded project aimed at understanding the identity and plasticity of regulatory T (Treg) cells, in the context of autoimmunity.

The primary objectives include:

1. to compare central Treg cell identity and function programs between mice and men in normal physiology and autoimmunity in collaboration with project partners
2. elucidate the transcriptional networks regulated by FoxP3 and c-Rel in Treg cells and screen for novel critical regulators of Treg identity and function in autoimmune contexts
3. study how context-specific cytokine milieus affect Treg identity as well as plasticity and functionally validate engineered Treg cells with distinct anti- or pro-inflammatory features

Key Responsibilities:

1. Conduct wet lab experiments to generate data describing the context-dependent Treg identity and underlying transcriptional networks.
2. Collaborate with project partners.
3. Contribute to the preparation and analysis of data for publication and presentations.

Your profile:

1. Strong background in T cell biology/immunology.
2. Hands-on experience with transgenic mouse models, including breeding and colony management.
3. Proficiency in preparing and processing lymphoid organs from mice.
4. Expertise in Flow Cytometry, particularly in multi-color FACS staining and cell population analysis.
5. Experience/Interest in single cell RNA sequencing experiments.
6. Excellent proficiency in English, both written and spoken.

We offer you:

1. EGYM well pass, corporate benefits and discounts (e.g. Käfer), cafeteria, sports and cultural offers, company bike
2. Free use of the library through a branch of the Munich City Library located in the building
3. Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as the subway, S-Bahn or tram
4. Company pension plan through the Federal and State Pension Institute (VBL)
5. Self-realization through a varied and technically demanding job with interdisciplinary cooperation between various departments of the MRI

We look forward to your application!

Please submit your complete application documents by e-mail including

1. reference number 24_09_053
2. your preferred starting date.

E-Mail:

If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.

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