Internship in Pharmacokinetic sciences

Job ID REQ-10050238 Apr 25, 2025 Switzerland Summary Data Evaluation of pharmacokinetic parameters in human FcRN mice, allometric scaling and data evaluation of FcRn binding characterization using in vitro models Location: Campus Basel Duration: 3 months Start date: as soon as possible About the Role This project aims to evaluate the feasibility and effectiveness of using in vitro and in vivo models to characterize FcRn binding and to estimate the elimination PK parameters of antibody drug candidates in human. This will include: data analysis, comparison of in-vitro and in-vivo data, data mining, in silico models, reporting. Major accountabilities: – This internship will focus to work on a discovery pharmacokinetic screening project using a new established hMice model in collaboration with a non-profit organization outside of Novartis (in life part will be outsourced) – Work on your own Pharmacokinetic evaluation and modeling project under the guidance of senior-level quantitative scientists – Analyze data from various sources (e.g., animal studies) as well as in vitro investigations – Attend seminars and other activities to enhance the understanding of the drug development process – Present your project results to quantitative scientists and other stakeholders Minimu Requirements: – Current enrolled in Master or PhD studies in Pharmacokinetic or Mathematics/Statistics, Physics, Bioinformatics, Biomedical Sciences or Pharmaceutical Sciences/Pharmacy – Good theoretical knowledge in antibody pharmacokinetics as well as PK analysis (e.g. NCA, compartmental modelling) and data analysis – Ideal candidate should have understanding of pharmacokinetics and predictive PK-PD modeling – Candidate should have proficiency with modelling and simulation software (NONMEM/Monolix, MatLab, R, WinNonLin/Phoenix – Experienced with data sciences (mathematical, biostastatistical data analysis) – Candidates must have excellent oral and written communication skills in English as well as strong problem-solving skills Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external) Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards Division Biomedical Research Business Unit Pharma Research Location Switzerland Site Basel (City) Company / Legal Entity C028 (FCRS = CH028) Novartis Pharma AG Functional Area Others Job Type Full time Employment Type Early Career (Befristet) Shift Work No Apply to Job(link is external)