- Utilize modern sequencing-based molecular biology approaches (RNA-seq, ChIP-seq, HiChIP, Hi-C, PRO-seq, etc.) to test hypotheses and examine epigenetic and gene regulatory mechanisms controlling pancreatic tumor cell identity and therapy response.
- Bioinformatic analysis and interpretation of data followed by hypothesis testing and generation.
- Perform multiplex immunofluorescence staining to confirm gene regulatory mechanisms in primary tumor tissue using multispectral imaging with an Akoya PhenoImager.
- Perform tissue-based preparation of histological samples (FFPE tumor material) for single cell RNA-sequencing using the 10X Genomics technology.
- Perform advanced cell culture experiments to examine the effects of drug treatment in various translational model systems.
- Participation in internal or external research collaborations.
- Documentation of work procedures, data acquisition and analyses.
Qualifications
- Strong work ethic and high level of self-motivation.
- Applicants must be enrolled in an accredited Master of Science program in a related field (biology, molecular biology, molecular medicine, or similar).
- Basic experience with cell culture, transfections, etc.
- Experience with molecular biology techniques (real-time PCR, Western blot, etc.).
- Strong interest in learning and gaining proficiency in bioinformatic analyses.
- Independent, goal-oriented and structured way of working and ability to work in a team.
- Confident written and spoken English skills.
- Dedication to making a difference in the lives of cancer patients through innovative and impactful research.
Additional Information
- An exciting and international research environment.
- Excellent experience and expertise in modern epigenetic methods.
- Outstanding bioinformatic expertise.
- Extensive modern infrastructure for all methods related to the project.
- Working in a committed team, characterized by mutual appreciation and support.
- Proven track record of successfully supervising many students to completion.
- Long track record in gene regulation and cancer research.
Contact:
Scientific Director
E-mail:
#J-18808-Ljbffr

Kontaktperson:
ADP HR Team