Biomarker Therapeutic Area Head -Neuroscience

ppSalary Range: CHF169,400.00 - CHF314,600.00 Band Level 7 Job Description Summary #LI-Hybrid Location: Basel Bringing life-changing medicines to millions of people, Novartis sits at the intersection of cutting-edge medical science and innovative digital technology. As a global company, the resources and opportunities for growth and development are plentiful including global and local cross functional careers, a diverse learning suite of thousands of programs an in-house marketplace for rotations project work. With strong medicines pipeline our current transformation will not just deliver growth for our business but continue to allow us to bring innovative medicines to patients quickly. Biomarkers are critical components of translational research, enabling robust therapeutic and mechanistic hypothesis testing in early clinical development, and as precision medicine enablers e.g. defining patient subpopulations, predicting patient responses, and use as diagnostics. The Therapeutic Area Head (TABH) in Biomarker Development (BMD) in Translational Medicine, partners with other Disease area, Translational Medicine, Global Development, and Commercial leadership for the development and implementation of innovative, complex, exploratory biomarker strategies, independent of clinical program stage, and provides an effective interface for transitioning projects to later stage development. The BMD TABH leads and develops a dedicated group of biomarker project team leads (BML) and therapeutic area biomarker leads (TABL) to develop and oversee clinical project strategies, plans and timelines. /ph3Key Responsibilities /h3ulliKey leader to identify, develop, and drive disease, mechanistic biology, translational pharmacology and precision medicine approaches for the Neuroscience and DARe (Diseases of Aging and Regenerative medicine) portfolio, leveraging diverse biomarker modalities e.g. genetics, genomics, proteins, cells, imaging, digital devices and technology/data science strategies /liliStrategic decision-making and executive oversight in indication / patient selection, biomarker strategy formulation, and investigations into drug mechanisms of action /liliResponsible for delivering clinical project and disease biology “fit for purpose” biomarker strategies/plans across the Neuroscience and DARe (Diseases of Aging and Regenerative medicine) portfolio and leading reviews at Disease Area Decision Boards (DADBs), Biomarker Forum, Biomarker and Diagnostic Review Committee, TDSCs and governance boards /liliLeads, mentors and develops a dedicated group of biomarker project team leads (BML) and therapeutic area biomarker leads (TABL) to develop and oversee clinical project strategies, plans and timelines /liliProvides Novartis disease biomarker leadership internally and externally to drive innovative mid-long term disease area initiatives/consortium across biomarker/clinical study designs, endpoints, diagnostics and discovery strategies /liliProvides insight into optimal selection of exploratory, “fit for purpose” and validated biomarkers (across modalities e.g. genetic, genomic, soluble, cellular, imaging, digital) to address clinical and biological mechanism questions, trial endpoints and identify responsive patient subpopulations /liliWorks in close collaboration with other functions in Biomedical Research and Development (e.g. TMDP, CSI, PKS, PCS, RA, DDCI, DAs and DUs) to provide expertise, optimize portfolio value and issue resolution /liliResponsible for high-quality contributions and review of study protocols, clinical study reports, Integrated Development Plans, and Clinical Pharmacology Plans /liliSupports high quality internal and regulatory submissions/decisions e.g. proof of concept/mechanism, dose selection/escalation, safety and competitive differentiation claims /liliAttends meetings with external parties including investigators, outside experts, and health authorities, as needed /li /ulh3Essential Requirements /h3ulliPhD and/or MD desirable with broad biology/technology knowledge in the clinical biomarker field /lilimedical and/or clinical genetics experience desired /liliDeep expertise in drug development /liliSubstantial impactful experience working in Pharma and/or biotechnology RD business functions, leading internal and external high performing diverse teams and matrix organizations /liliScientific excellence and clinical expertise in neurodegeneration, neuroimmunology, neuromuscular and neurogenetic diseases/biology evidenced by significant contributions to the field /liliDemonstrated technical and scientific expertise in multiple areas for development of innovative biomarker solutions with experience in working across key modalities (eg xRNA, AAV, biotherapeutics and small molecules) /liliWell-developed interpersonal skills with good presence and ability to influence and negotiate with senior leadership, experienced presenter and communicator /liliStrong track record of people leadership /liliRecognized internally and internationally externally by key stakeholders /liliin depth understanding of external environment/trends /lilidevelops a strong professional network /liliFluent in oral and written English /liliother languages e.g. German, French, Italian useful but not required /li /ulh3Benefits Rewards /h3ulliExpected Annual Base Salary Range for role: 169,400.00 - 314,600.00 CHF Annual /liliThe base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically. /liliIn addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. /liliWe also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. /liliIn addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave. /liliLong-term equity awards granted at group level may also be part of your package. /liliFurther details will be provided during the application process. /liliPay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics. /li /ulh3Commitment to Diversity and Inclusion / EEO /h3pNovartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve. /ppAccessibility and accommodation Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e‑mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message. /ph3Skills Desired /h3ulliAccountability /liliBiotechnology /liliClinical Research /liliClinical Trials /liliCollaboration /liliData Science /liliDecision Making /liliDrug Development /liliInfluencing Skills /liliLeadership /liliMedical Research /liliMentorship /liliMolecular Biology /liliProcess Simulation /liliStakeholder Engagement /liliStakeholder Management /liliStrategic Leadership /li /ulpIn the context of China Cross-Border Data Transfer (CBDT) policy, if you need to apply for a position in China, please go to the local Recruiting System TaleNov . /p /p #J-18808-Ljbffr