PhD Position – RNA localization regulation and function

Organisation/Company Goethe University Research Field Biological sciences Researcher Profile First Stage Researcher (R1) Country Germany Application Deadline 15 May 2025 – 23:00 (UTC) Type of Contract To be defined Job Status Full-time Hours Per Week To be defined Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The research team of Gabrijela Dumbović is inviting applications for a motivated PhD student (m/f/d, 65%, E13 TV-G-U) to join our project on RNA biology. For more information about our work, please visit our lab website.

About the position

We study the dynamic mechanisms underlying the subcellular localization regulation of coding and long non-coding RNAs in both healthy and disease states. Our interdisciplinary approach combines advanced imaging with molecular and computational techniques to explore how RNA localization influences cellular function and pathology. Our team is looking for experimental and/or computational applicants .

Key responsibilities

The successful candidate will utilize targeted and multiplexed single-molecule RNA imaging methods to visualize RNA molecules at high resolution. In addition, the candidate will investigate the interactions between RNAs and proteins that regulate their localization and function. They will also employ high-throughput sequencing techniques such as RNA-seq to profile RNA populations and uncover regulatory patterns, and apply genome editing tools such as CRISPR-Cas9 to manipulate RNA regulatory motifs and assess functional outcomes. Computational skills in data analysis are highly valued.

Candidate profile

The ideal candidate will be passionate about molecular biology and eager to contribute to innovative research. A strong foundation in experimental techniques and a keen interest in RNA biology are highly desirable, background in computational biology is a plus.

We offer

Our laboratory offers a stimulating and collaborative working environment with state-of-the-art infrastructure and unique professional career development opportunities. We are a part of the CPI Cluster of Excellence , TRR267 on non-coding RNAs in the cardiovascular system , and SCALE with numerous opportunities to engage with researchers working in diverse fields. We value diversity and encourage applicants from all backgrounds to apply. The contract is initially limited to two years, with the possibility of extension.

How to apply

Interested candidates should send their cover letter and CV as a single PDF to Dr. Gabrijela Dumbovic by email.

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