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- Aufgaben: Dive into groundbreaking research on developmental robustness in a mouse model for Fibrodysplasia Ossificans Progressiva.
- Arbeitgeber: Join the University of Basel's Department of Biomedicine, a leader in biological sciences.
- Mitarbeitervorteile: Gain hands-on experience with advanced techniques and methodologies in a collaborative research environment.
- Warum dieser Job: Contribute to impactful research that could lead to therapeutic strategies for congenital diseases.
- Gewünschte Qualifikationen: Ideal for master's students eager to explore molecular and cellular biology.
- Andere Informationen: Flexible start date; engage in seminars and enhance your scientific communication skills.
Das voraussichtliche Gehalt liegt zwischen 36000 - 60000 € pro Jahr.
Organisation/Company: University of Basel
Department: Department of Biomedicine
Research Field: Biological sciences » Biology
Researcher Profile: Leading Researcher (R4) Positions
Country: Switzerland
Application Deadline: 31 Mar 2025 – 12:00 (Europe/Zurich)
Type of Contract: Not Applicable
Job Status: Not Applicable
Offer Starting Date: 1 Feb 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The basis for developmental robustness against disease in a mouse model for Fibrodysplasia Ossificans Progressiva.
Developmental Genetics
Department Biomedicine, University of Basel
Embryonic development is a marvel of biological complexity as gene expression, cellular development and differentiation are seamlessly integrated across tissue, organ and the organism as a whole. Despite the susceptibility to molecular and cellular disturbances, an intrinsic robustness within embryos often prevails, shielding developmental processes from genetic perturbations. Our research has unveiled fascinating insights into the molecular basis of developmental robustness and we are now applying this knowledge to explore the underlying mechanisms of developmental robustness in congenital diseases, an emerging field of significant biomedical interest. Fibrodysplasia Ossificans Progressiva (FOP) is a rare human condition characterized by abnormal bone formation triggered by the R206H mutation in the ACVR1 receptor which leads to excessive BMP signaling. Intriguingly, the manifestation of FOP occurs postnatally despite embryonic activity of the receptor and the goal of this project is to uncover why embryos seem unaffected by the condition.
Project Aims:
- Aim1: By investigating cellular and molecular changes in FOP mutant limb buds from the earliest stages, we aim to identify the compensatory mechanisms that protect the embryo from disease manifestation.
- Aim2: The effects of excessive BMP signaling on FOP disease progression in the absence of BMP antagonism will be investigated genetically. Cellular, molecular, and phenotypic alterations will be analysed in embryos. Elucidating the mechanisms that enable embryos to evade or delay the onset of disease symptoms will be relevant for identifying potential therapeutic strategies for FOP.
This project encourages student interaction with several group members.
Methodologies:
Over approximately 9 months, the research project will immerse the student in a diverse array of molecular and cellular techniques. These include mouse genetics to investigate gene interplay affecting disease onset, phenotypic studies on cartilage and bone formation and the isolation and 3D culturing of limb mesenchymal progenitors from both wild type and FOP model for comparative analysis of molecular and cellular differentiation. Advanced techniques such as fluorescent RNA in situ hybridization (HCR) and immunofluorescence will enable detailed cellular studies.
This project provides the student with a valuable combination of scientific methodology, analytical thinking, and innovative research skills. Participation in research seminars, journal clubs, and the master thesis writing process will strengthen their ability to effectively communicate scientific findings in English, offering an enriching educational and research experience.
This project can be started as agreed with the master student.
Interested? Then drop us an email with your CV to arrange for an interview and project discussion. We look forward to hearing from you!
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Master project "The basis for developmental robustness against disease in a mouse model for Fib[...] Arbeitgeber: euraxess.ec.europa.eu - Jobboard
Kontaktperson:
euraxess.ec.europa.eu - Jobboard HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: Master project "The basis for developmental robustness against disease in a mouse model for Fib[...]
✨Tip Number 1
Familiarize yourself with the latest research on Fibrodysplasia Ossificans Progressiva (FOP) and related developmental genetics. This will not only help you understand the project better but also allow you to engage in meaningful discussions during your interview.
✨Tip Number 2
Highlight any relevant experience you have with molecular and cellular techniques, especially those mentioned in the job description like mouse genetics or immunofluorescence. Being able to discuss your hands-on experience can set you apart from other candidates.
✨Tip Number 3
Prepare to discuss how you can contribute to the collaborative environment of the research team. Emphasizing your ability to work well with others and your enthusiasm for student interaction can demonstrate that you are a good fit for the project.
✨Tip Number 4
Since effective communication is key in this role, practice explaining complex scientific concepts in simple terms. This will help you convey your ideas clearly during the interview and show that you can communicate effectively with diverse audiences.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: Master project "The basis for developmental robustness against disease in a mouse model for Fib[...]
Tipps für deine Bewerbung 🫡
Understand the Project: Take the time to thoroughly read the project description. Familiarize yourself with the aims and methodologies outlined, as this will help you tailor your application to demonstrate your relevant skills and interests.
Craft a Tailored CV: Ensure your CV highlights your academic background, relevant research experience, and any specific skills related to molecular and cellular techniques mentioned in the job description. Emphasize your analytical thinking and communication skills.
Write a Compelling Email: When reaching out via email, introduce yourself briefly and express your interest in the project. Mention why you are a good fit based on the project aims and methodologies. Attach your CV and ensure the email is professional yet personable.
Prepare for the Interview: If you get invited for an interview, prepare by reviewing potential questions about your research experience and understanding of the project. Be ready to discuss how your background aligns with the goals of the research and what you hope to learn.
Wie du dich auf ein Vorstellungsgespräch bei euraxess.ec.europa.eu - Jobboard vorbereitest
✨Understand the Research Focus
Make sure you have a solid grasp of the project's aims, especially regarding developmental robustness and Fibrodysplasia Ossificans Progressiva. Familiarize yourself with the key concepts and methodologies mentioned in the job description to demonstrate your genuine interest and knowledge during the interview.
✨Prepare for Technical Questions
Since the project involves advanced techniques like mouse genetics and immunofluorescence, be ready to discuss your experience with these methods or similar ones. Highlight any relevant coursework or projects that showcase your technical skills and analytical thinking.
✨Show Enthusiasm for Collaboration
The project encourages interaction with group members, so express your enthusiasm for teamwork and collaboration. Share examples from your past experiences where you successfully worked in a team setting, emphasizing your communication skills and ability to contribute to group dynamics.
✨Communicate Your Research Interests
Be prepared to discuss your own research interests and how they align with the goals of the project. This is a great opportunity to show how your background and aspirations fit into the broader context of the research being conducted at the University of Basel.
