Principal Scientist (m/f/d) - Oncology

Site Name: Berlin Buch Campus
Posted Date: Jul 4 2025

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.

Principal Scientist (m/f/d) – Oncology

We are looking for a Principal Scientist to join the newly established NiVP (Novel in vitro Phenomics) team. This role is ideal for someone passionate about developing innovative in vitro models that drive meaningful impact for patients.
NiVP is part of the Oncology Translational Research (OTR) team at GSK and is embedded in a collaborative network across OTR and beyond, supporting both preclinical and clinical development programs within the GSK Oncology Therapeutic Area.
The successful candidate will join a team currently being built across Berlin and Stevenage, with a core focus on establishing cutting-edge organoid models. These models will be leveraged across a range of translational applications, from chemosensitivity profiling to molecular engineering approaches for biomarker discovery and target validation.
Location: Berlin

Key responsibilities:
This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:

• Establish and execute cell culture protocols for the growth and expansion of patient-derived organoids from various tumor entities, including both solid tumors and hematological malignancies.
• Developing co-culture protocols for patient-derived organoids and components of the microenvironment of human diseases, including but not limited to cancer.
• Oversee the development, monitoring, and evaluation of patient-derived organoids (e.g., cell density, proliferation rate) utilizing advanced techniques in cell and molecular biology according to best practices and quality control standards.
• Organize and contribute to collaborative projects with both academic and industry research partners.
• Coordinate workflows as part of a cross-functional project team.
• Collect, analyze, and interpret experimental results; summarize findings in clear reports and presentations for both internal and external stakeholders.

Why you?
Key Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:

• Ph.D. in Cell Biology, Oncology, Immunology or a related field, with postdoctoral or equivalent research experience.
• Strong background in cell biology, including cellular reprogramming, disease modeling and complex cell culture, ideally with multidisciplinary training.
• Proven expertise in cell culture techniques, particularly with primary samples (human biopsies, resections or buffy coats) and patient-derived organoids; experience with variations of culture systems (2D, 3D and/or co-culture).
• Skilled in cellular and molecular biology methods relevant to translational research.
• Independence in forming scientific hypotheses; executing, analyzing, validating results and optimizing procedures when needed.
• Effective communicator with the ability to collaborate across disciplines and engage with both peers and senior stakeholders.

Preferred Requirements:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Experience in cellular profiling methods such as flow cytometry analysis and FACS sorting, with hands-on experience in CRISPR on organoids considered an advantage.
• Proven track record of scientific publications or achievements.
• Experience collaborating with biopharmaceutical industry partners.

Find out more:

Our approach to R&D

Annual Report

Product Pipeline

#EBDE

#LI-GSK

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK\’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at

#J-18808-Ljbffr