Head Biochemistry and Structural Biology Lab (m/f/d)

Head Biochemistry and Structural Biology Lab (m/f/d)

Country: Germany

Department: Research & Development

Job ID: 44294

If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development , we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.

What the job looks like

1. Generate impactful human cell-based and other in vitro biochemistry and structural biology data to support our small molecule and genetic medicine projects.
2. Explore target mechanisms and propose and evaluate novel targets.
3. Propose, manage and drive internal programmes.
4. Represent the Biochemistry and Structural Biology Lab in cross-disciplinary project teams and in external collaborations with academic, biotechs and CROs.
5. Ensure high quality experimentation (internal and external), analysis and data management.
6. Use scientific expertise to guide and develop team colleagues in their assignments.
7. Foster open and clear communication within the team and across different functions.

What you’ll bring to the table

• A PhD in biochemistry or structural biology or a closely related discipline with a minimum of 5 years’ work experience in an industrial drug discovery setting.
• Experience and proven track record in the development and use of biochemical assays to study different molecular target classes (e.g. ELISA assays, biomarker detection, protein purification, protein-protein or protein-ligand interactions, protein turn over, enzymatic assays, capillary-based immunoassays and automated Western blot analysis).
• And/or experience in structural biology and biophysical techniques (e.g. surface plasmon resonance, microScale Thermophoresis, Spectral Shift, differential scanning fluorimetry, dynamic Light Scattering, calorimetry, x-ray crystallographic analysis, electron cryo microscopy).
• Experience with RNA-modulating therapies (ASO, siRNA) incl. targeted delivery is an advantage.
• Ability to set up novel techniques in a result-oriented manner.
• A passion for investigating molecular mechanisms and for exploring targets and a good understanding on how targets/pathways can be modulated in pain, neuroscience in general and adjacent disease areas.
• A deep knowledge of human chronic pain disorders is an advantage.
• Excellent mathematical skills and data analysis capabilities and a drive for data quality and high-quality documentation.
• Experience and motivation to manage labs.
• Pragmatic, optimistic, problem-solving attitude with natural curiosity; someone who will reach out proactively, internally and externally, to source alternative solutions.
• Excellent organizational and communication skills with a high level of team spirit and pro-activity.
• Ability to challenge the status quo and to embrace change with an open mind.

______________________________________

“ Are you an enthusiastic and experienced scientist with passion to design human confidence-building biochemical experiments and to learn from structural models to design better molecules? Would you like to help us to bring innovative medicines to pain patients? Then we are looking forward to your application.”

Gregor Bahrenberg, the Hiring Manager

Grünenthal is a global leader in pain management and related diseases. As a science-based, fully-integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focusing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 27 countries across Europe, Latin America and the US. Our products are available in approx. 100 countries. In 2023, Grünenthal employed around 4,400 people and achieved revenues of € 1.8bn.

#J-18808-Ljbffr