Postdoctoral Scientist Chemistry Innovations for Oligonucleotide Delivery (m/f/d)

Postdoctoral Scientist Chemistry Innovations for Oligonucleotide Delivery (m/f/d)

Country: Germany

Department: Research & Development

Job ID: 44395

Graduate | Temporary | Full-time | On-Site

If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development , we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.

For our 24 month Postdoc Programme, we are looking for top performers, lateral thinkers, visionaries, team players & creative heads! You will build up your knowledge and personal network while working on impactful projects. We offer you one-on-one coaching by experienced leaders and trainings to support you in your personal and professional growth.

What the job looks like
Each day you’ll enjoy a variety of challenges, such as:

• Designing and synthesizing novel oligonucleotide conjugates that enhance delivery to sensory neurons.
• Collaborating with a delivery mechanism-focused postdoc to form a center of excellence in oligonucleotide delivery.
• Exploring siRNA and ASO modifications, focusing on innovative backbones, linkers, and conjugates to improve delivery efficacy.
• Leveraging external partnerships in small molecule, peptide and antibody synthesis to refine and expand delivery capabilities.

What you’ll bring to the table
To make the most of this role and truly thrive, you should have:

• Ph.D. in Organic Chemistry, Chemical Biology, or related field, with hands-on experience in phosphoramidite and oligonucleotide synthesis.
• Expertise in linker and conjugate design at both terminal and internal positions of the oligo.
• Experience with designing and optimizing conjugates for enhanced siRNA/ASO delivery (e.g., via click chemistry and related methods), with proficiency in advanced analytical methods such as HPLC and Mass spectrometry.
• Ability to work closely with biological scientists to bridge chemistry innovations with delivery model requirements.
• Proactive, open-minded, and positive to the ideas of others with strong curiosity and enthusiasm for learning novel techniques.
• Fluent business English language skills in speaking and writing.
• Programming skills in python (or related field) to analyze oligo specific sequence data is a plus but not a must.
• Broad international &/or intercultural working experiences is a benefit.

COME ON BOARD & LOOK FORWARD TO:

• Attractive compensation and extensive social benefits.
• Wide range of company benefits e.g. health initiatives & sports activities.
• Top modern international working environment.

Grünenthal is a global leader in pain management and related diseases. As a science-based, fully-integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion.

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