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- Aufgaben: Dive into cutting-edge research on TSC22D4 and its role in liver fibrosis.
- Arbeitgeber: Join a leading clinic focused on endocrinology and diabetes research in Heidelberg.
- Mitarbeitervorteile: Enjoy 30 days of vacation, flexible childcare options, and a supportive work environment.
- Warum dieser Job: Contribute to impactful research with opportunities for publication and interdisciplinary collaboration.
- Gewünschte Qualifikationen: Must have an MSc in biological sciences and experience in metabolism research.
- Andere Informationen: Applications accepted until 31.01.2025; reach out to Dr. Bilgen Ekim for more info.
Das voraussichtliche Gehalt liegt zwischen 36000 - 60000 € pro Jahr.
Your tasks
TSC22D4 is an evolutionarily conserved protein with a long stretch of intrinsically disordered region (IDR) which contains multiple phosphorylation sites. Patients with type 2 diabetes and liver fibrosis have elevated TSC22D4 protein levels in their liver. In this project, you will investigate whether phosphorylation of TSC22D4 contributes to liver fibrosis by performing experiments both in cell culture and in mouse models. The tasks will involve overexpressing wild type, phospho-defective, and phospho-mimetic TSC22D4 mutants in primary hepatocytes or in mouse livers to address whether TSC22D4 phosphorylation plays a role in apoptosis, inflammation, and liver injury. The techniques for these measurements will mostly include RNA and protein extraction from the cells or the liver tissue, qPCR analysis, western blotting, ELISA, and immunohistochemical stainings.
Your Profile
- A highly motivated and hardworking student with a MSc degree in biological sciences and a strong academic background in molecular and cellular biology.
- Demonstrated interest and experience in metabolism research including cell culture work and mouse models as well as excellent communication and teamwork skills.
What we offer
- Goal-oriented, individual training and development opportunities (e.g. Enrollment opportunity at HBIGS Graduate School)
- Possibility to publish scientifically is offered and supported
- Regular team meetings
- Interdisciplinary cooperation with Helmholtz Diabetes Center, Munich
- The opportunity to work on translational research from bench to bedside
- Collectively agreed remuneration, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
Contact & Application
For further information please contact Dr. Bilgen Ekim via email.
Interested?
Applications will be accepted until 31.01.2025 via e-mail.
Klinik für Endokrinologie, Diabetologie, Stoffwechselkrankheiten und Klinische Chemie
69120 Heidelberg
#J-18808-Ljbffr
PhD Student (m/f/d) Arbeitgeber: Heidelberg Institute of Global Health
Kontaktperson:
Heidelberg Institute of Global Health HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: PhD Student (m/f/d)
✨Tip Number 1
Make sure to highlight any relevant experience you have with cell culture and mouse models during your conversations. This will show your hands-on skills and understanding of the techniques mentioned in the job description.
✨Tip Number 2
Network with professionals in the field of metabolism research, especially those who have experience with TSC22D4 or similar proteins. Engaging in discussions can provide insights and potentially valuable connections.
✨Tip Number 3
Prepare to discuss your academic background in molecular and cellular biology in detail. Be ready to explain how your studies have prepared you for this specific research project.
✨Tip Number 4
Familiarize yourself with the latest research on TSC22D4 and its role in liver fibrosis. Being knowledgeable about current findings will demonstrate your genuine interest in the topic during interviews.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: PhD Student (m/f/d)
Tipps für deine Bewerbung 🫡
Understand the Project: Make sure to thoroughly read the job description and understand the research project involving TSC22D4. Highlight your relevant experience in metabolism research, cell culture, and mouse models in your application.
Tailor Your CV: Customize your CV to emphasize your MSc degree in biological sciences and any specific coursework or projects related to molecular and cellular biology. Include any relevant lab techniques you are proficient in, such as qPCR, western blotting, and ELISA.
Craft a Strong Cover Letter: Write a compelling cover letter that showcases your motivation for the position. Discuss your interest in liver fibrosis research and how your skills align with the tasks outlined in the job description.
Proofread Your Application: Before submitting, carefully proofread your application materials for any errors or typos. A well-presented application reflects your attention to detail and professionalism.
Wie du dich auf ein Vorstellungsgespräch bei Heidelberg Institute of Global Health vorbereitest
✨Show Your Passion for Research
Make sure to express your enthusiasm for metabolism research and the specific project on TSC22D4. Share any relevant experiences or projects you've worked on that demonstrate your commitment to this field.
✨Highlight Your Technical Skills
Be prepared to discuss your experience with techniques like RNA and protein extraction, qPCR, western blotting, and ELISA. Providing specific examples of how you've used these methods in past research will showcase your hands-on skills.
✨Demonstrate Teamwork and Communication Skills
Since the role involves interdisciplinary cooperation, emphasize your ability to work in teams. Share examples of successful collaborations and how you effectively communicated with colleagues in previous projects.
✨Ask Insightful Questions
Prepare thoughtful questions about the research project, the team dynamics, and the opportunities for publication. This shows your genuine interest in the position and helps you assess if it's the right fit for you.
