Master Thesis - Development of ligand conjugated lipid nanoparticles for targeted T cell delivery (f/m/x)

Master Thesis – Development of ligand conjugated lipid nanoparticles for targeted T cell delivery (f/m/x) 102778 Neuherberg near Munich At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives. The Institute for Intelligent Biotechnologies (iBIO) develops and implements tools to analyze biological samples\‘ 3D structure and molecular identity. At iBIO, we bring together cutting-edge science from biology, chemistry, engineering, and computer applications. Our overarching aim is to obtain a holistic view of interconnected biological systems in health and disease. We develop clearing technologies for cellular-level imaging and deep learning algorithms (AI) to analyze large imaging and molecular data in a robust and unbiased way. Worldwide media, including New York Times, Wall Street Journal, and Süddeutsche Zeitung, have highlighted our research. You can find out more about us here . We are offering an exciting Master’s thesis project for a motivated student (f/m/x) . You will prepare lipid nanoparticles carrying targeting ligands for enhanced cell specificity and and work with lipid nanoparticles carrying targeting ligands for enhanced cell specificity. Your tasks Optimization of the targeting ligand conjugation to nanoparticle surface (conjugation chemistry parameters, purification methods) Characterization of the nanoparticles (DLS, zeta potential, encapsulation efficiency, attachment efficiency) In vitro functionality assessment (cytotoxicity, cellular uptake, delivery and expression efficiency, cell specificity) Your profile Enrolled in a Master\’s program Basic biochemistry knowledge and experience with laboratory work Theoretical knowledge about nanoparticles and nucleic acid delivery Experience with conjugation techniques, lipid nanoparticles, and cell culture is a plus Structured work style and the ability to work in a team are required This position has a fixed term, depending on the requirements of your study program. Managing Directors Matthias Tschöp and Mike Frieser: \“We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful.\“ Interested in applying? If you have any questions, feel free to contact Stefanie Reitinger, stefanie.reitinger@helmholtz-munich.de, who will be happy to help. Our recruiting is decentralized – your application will be reviewed directly by the specialist department in which you could work in the future. More information about our application process Please send your application only via our online application tool and with the following documents: CV CV Cover letter Degrees/Diplomas/Certificates We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference. Institute for Intelligent Biotechnologies