Master’s Thesis position in B cell Immunology (f/m/x)

Master’s Thesis position in B cell Immunology (f/m/x) 102779 Neuherberg near Munich At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives. B-cell responses are essential for humoral immunity against pathogens because they lead to the generation of antibody-secreting cells that produce large amounts of antigen-specific antibodies. These cells also have the potential to become quiescent and long-lived, which is fundamental for immunological memory against pathogens. B-cell responses are also key mediators of diseases, such as allergies, antibody-mediated autoimmunity, and malignancies. Our Group at the Institute of Allergy Research (IAF) /Center for Allergy and Environment (ZAUM) at Helmholtz and the Technical University of Munich focuses on studying the processes of B lymphocyte activation and differentiation into effector B cells, such as antibody-secreting cells and memory B cells. We are seeking a highly motivated Master’s student (f/m/x) to join our research team for a thesis project. Your tasks The lab has previously established an in vivo model system for pooled single-guide RNA (sgRNA) CRISPR/Cas9 screening, which has led to the identification of several novel regulators of B cell-mediated responses. Building on this expertise, the student’s project will focus on developing new CRISPR/Cas9 screening systems to uncover regulators of effector B cells in mouse models of type 2 immunity and allergic responses. Your profile Practical scientific experience and a strong theoretical background in fields such as immunology, genetics, epigenetics, molecular biology or biochemistry. An interest in research using mice as animal models. A high degree of scientific curiosity, creativity, flexibility, and enthusiasm for working in an interdisciplinary and international team. This position has a fixed term, depending on the requirements of your study program. What we offer: Work-Life-Balance Flexible working hours and flexi-time models Health Promotion Sports, company doctor, mental health initiatives Personal Development Comprehensive in-house training and development opportunities Managing Directors Matthias Tschöp and Mike Frieser: \“We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful.\“ Interested in applying? If you have any questions, feel free to contact Dr. Lesly Calderon Dominguez, lesly.calderon@helmholtz-munich.de, who will be happy to help. Our recruiting is decentralized – your application will be reviewed directly by the specialist department in which you could work in the future. More information about our application process Please send your application only via our online application tool and with the following documents: CV CV Cover letter Degrees/Diplomas/Certificates Contact details for at least two referees We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference. Institute of Allergy Research