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- Aufgaben: Join our team to develop cutting-edge single-cell RNA-seq technologies and study gene expression dynamics.
- Arbeitgeber: Helmholtz Munich is a leader in biomedical research, improving health through innovative solutions.
- Mitarbeitervorteile: Enjoy 30 days of annual leave, flexible workdays, and support for relocation and integration.
- Warum dieser Job: Make a real impact in health research while working with top scientific talents in an inclusive environment.
- Gewünschte Qualifikationen: PhD in Systems Biology or related field, with strong publication record and experience in computational and experimental work.
- Andere Informationen: We value diversity and encourage applications from all backgrounds; initial contract is for 2 years.
Das voraussichtliche Gehalt liegt zwischen 42000 - 60000 € pro Jahr.
Postdoc (f/m/x) in time-resolved single-cell omics and stem cell biology
102622
Full time
39 hrs./week
Neuherberg near Munich
We are Helmholtz Munich. We discover breakthrough solutions for better health in a rapidly changing world.
We improve people’s quality of life through excellent research. Why not join us and make a difference?
TheHelmholtz Pioneer Campus (HPC) founded and funded by Helmholtz Munich stands for the intelligent fusion of biomedical sciences, engineering and digitization. At HPC, top scientific talents from across the globe work together on the development of novel solutions that make a difference in the prevention, diagnosis and treatment of diseases.
We are looking for a postdoc (f/m/x) to join our team to develop new time-resolved single-cell RNA-seq technologies and study the interplay between gene oscillations and cellular decision making in stress and during differentiation.
At the Battich lab we are an interdisciplinary team that loves to develop cutting-edge quantitative methods for single-cell genomics and combine them with cellular phenotyping using high-content confocal microscopy. We design data-driven approaches and build quantitative predictive models and use state-of-the-art machine-learning to gain insights into the cellular processes we study.
Your tasks
- Design and characterize new single-cell sequencing approaches to study gene expression dynamics and oscillations, based on metabolic labelling of RNA.
- Characterize the genome wide dynamics in expression in different differentiation systems such as models of embryo segmentation and/or neural differentiation.
- Work in a team to build quantitative models of gene expression dynamics based on interpretable AI.
- Elucidate mechanisms of how transcriptional dynamics propagate through the genome via gene regulatory networks.
- Analyse and integrate diverse datasets (e.g., single-cell genomics, proteomics and high-throughput fluorescent microscopy).
- Use CRISPR-Cas9 perturbation of chromatin regulators to investigate their effects on single-cell transcriptional dynamics.
Your profile
- PhD in Systems Biology, Genetics, Molecular & Cell Biology or a related quantitative biology discipline.
- Good publication record with evidence of independence (at least one first-author publication in an international journal).
- Interest and experience combining computational and experimental work, including demonstrated competency in scientific programming.
- Experience performing next-generation sequencing experiments, and/or CRISPR-Cas9 technology.
- Fluent in written and spoken English.
Desirable qualifications
- Experience with experimental work using stem cells or organoid model systems.
Benefits
- Career Development: Postdoc program, scientific training & career center with tailored offers
- Recreation: 30 days annual leave, flexi days, plus public holidays
- International Staff Service: Support with the relocation and integration process in Germany
- Health Promotion: Sports, company doctor, mental health initiatives
Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.
Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.
The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.
If you fulfil all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). The position has an (initial) fixed term of 2 years but may be extended under certain circumstances.
We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree.Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.
Interested in applying?
If you have any questions, feel free to contact Nicolas Battich, , who will be happy to help.
Your application should include
- CV
- Cover letter
- Degrees/Diplomas/Certificates
- Contact details for at least two referees
Helmholtz Pioneer Campus @Helmholtz Munich
Why join us?
Helmholtz Munich
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Helmholtz Pioneer Campus
Ingolstädter Landstraße 1
85764 Oberschleißheim
#J-18808-Ljbffr
Postdoc (f/m/x) in time-resolved single-cell omics and stem cell biology Arbeitgeber: Helmholtz Zentrum München
Kontaktperson:
Helmholtz Zentrum München HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: Postdoc (f/m/x) in time-resolved single-cell omics and stem cell biology
✨Tip Number 1
Make sure to highlight your experience with next-generation sequencing and CRISPR-Cas9 technology during the interview. Be prepared to discuss specific projects where you applied these techniques, as this will demonstrate your hands-on expertise.
✨Tip Number 2
Familiarize yourself with the latest advancements in single-cell RNA-seq technologies. Being able to discuss recent papers or breakthroughs in this area can show your passion and commitment to staying at the forefront of research.
✨Tip Number 3
Network with current or former members of the Battich lab or similar research groups. Engaging with them can provide insights into the lab culture and expectations, which can be invaluable during your application process.
✨Tip Number 4
Prepare to discuss how you would approach building quantitative models of gene expression dynamics. Think about specific methodologies you would use and be ready to explain your thought process clearly.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: Postdoc (f/m/x) in time-resolved single-cell omics and stem cell biology
Tipps für deine Bewerbung 🫡
Understand the Role: Make sure to thoroughly read the job description and understand the specific requirements and responsibilities of the postdoc position. Tailor your application to highlight how your skills and experiences align with these expectations.
Craft a Strong Cover Letter: In your cover letter, express your enthusiasm for the position and the research at Helmholtz Munich. Clearly outline your relevant experience in systems biology, genetics, or molecular biology, and mention any specific projects that relate to time-resolved single-cell omics.
Highlight Your Publications: Since a good publication record is essential, make sure to list your publications prominently in your CV. If you have a first-author publication, emphasize it as evidence of your independence in research.
Prepare References: Contact at least two referees who can speak to your qualifications and experiences. Ensure they are aware of the position you are applying for and can provide relevant insights into your capabilities in both experimental and computational work.
Wie du dich auf ein Vorstellungsgespräch bei Helmholtz Zentrum München vorbereitest
✨Showcase Your Research Experience
Be prepared to discuss your previous research projects in detail, especially those related to single-cell omics and stem cell biology. Highlight any innovative techniques you developed or utilized, and be ready to explain how they contributed to your findings.
✨Demonstrate Interdisciplinary Skills
Since the position involves combining computational and experimental work, emphasize your experience in both areas. Discuss specific programming languages or tools you are proficient in and how you've applied them in your research.
✨Prepare for Technical Questions
Expect questions about CRISPR-Cas9 technology and next-generation sequencing experiments. Brush up on the latest advancements in these fields and be ready to discuss how you would apply them in your future research at Helmholtz Munich.
✨Express Your Interest in Collaboration
The Battich lab values teamwork, so convey your enthusiasm for working in an interdisciplinary team. Share examples of past collaborations and how they enhanced your research outcomes, demonstrating your ability to contribute positively to the lab environment.
