We are seeking an experienced CAR Engineer/Immunologist to help develop next-generation engineered cell therapies. This role combines molecular immunology, synthetic biology, receptor engineering, and cellular engineering to advance innovative therapeutic programs. Key Responsibilities Design and optimize next-generation CARs to enhance specificity, activation, persistence, safety, and therapeutic efficacy. Engineer and characterize CARs across multiple immune-cell types. Develop and lead in vitro assays to assess cell phenotype, signaling, cytotoxicity, proliferation, and persistence. Advance novel synthetic biology approaches for immune-cell programming. Analyze complex datasets and establish scalable platforms to accelerate CAR discovery. Mentor and lead a team of scientists while contributing to scientific strategy, patents, publications, and presentations. Qualifications PhD, MD/PhD, or equivalent in Immunology, Molecular Biology, Bioengineering, or a related field. Experience in CAR-T, CAR-NK, CAR-M, or related cell therapy technologies. Strong expertise in molecular immunology, immune-cell biology, and CAR/receptor engineering. Experience with immune-cell functional assays and one or more delivery/editing platforms such as lentiviral vectors, LNP/mRNA delivery, or CRISPR-based technologies. Proven scientific leadership, project ownership, and team management experience. Preferred Experience with advanced CAR designs, including multispecific, logic-gated, armored, or inducible CARs. Knowledge of immune profiling, flow cytometry, and single-cell analysis. Experience in solid tumor immunology and tumor microenvironment research. Strong record of innovation through publications, patents, or therapeutic program development. Experience presenting to and collaborating with senior leadership and external stakeholders. #J-18808-Ljbffr
Principal Scientist in Epalinges Arbeitgeber: IGI
IGI in Lausanne bietet eine inspirierende Arbeitsumgebung, die Innovation und Zusammenarbeit fördert. Als Arbeitgeber legen wir großen Wert auf die berufliche Weiterentwicklung unserer Mitarbeiter und bieten zahlreiche Möglichkeiten zur Weiterbildung und Karriereförderung. Unsere moderne Ausstattung und der interdisziplinäre Austausch machen uns zu einem attraktiven Arbeitsplatz für Wissenschaftler, die an der Spitze der Antikörperforschung stehen möchten.
