About the Group Our group explores unconventional degradation pathways located in the “dark corners” of ubiquitin signalling - mechanisms often dismissed as niche or technically challenging. Following thisroute, we discovered protein arginine phosphorylation as a bacterial degron, developed BacPROTAC antibiotics against drug-resistant mycobacteria and determined the first structures of giant E3 ligases including HUWE1, RNF213, BIRC6 and UBR4. Furthermore, we showed that ATP serves as a danger signal directing RNF213 against bacterial invaders and that ZNFX1 ubiquitinates and compacts RNA into RNPs to control antiviral immunity. Together, these discoveries set the stage for the next challenge: understanding how giant E3 ligases extend ubiquitin signalling beyond proteins and control it across diverse cellular stress pathways.
About the Place The IMP is part of the Vienna BioCenter, one of the world's leading life science campuses. It offers access to state-of-the-art cryo-EM infrastructure, proteomics, imaging, high performance computing and a vibrant interdisciplinary community. Our lab is part of the "Ubiquitin & Friends" network, a local proteostasis hub comprising more than 100 researchers across twelve Vienna BioCenter groups, fostering collaboration and innovation.
Your Profile We are looking for a curious, ambitious, and collaborative scientist with …
a completed PhD in structural biology, biochemistry, or chemical biology
hands‑on experience in cryo‑EM data collection and processing (single‑particle analysis and/or cryo‑ET), in vitro reconstitution of multi‑protein assemblies and/or familiarity with RNA, DNA or lipid biochemistry
a publication record with first‑author contributions demonstrating this expertise
a strong interest in ubiquitin biology, innate immunity or proteostasis networks
What We Offer We offer a 3‑year postdoctoral position, with possibility of extension, and a few extras …
a unique head start: multiple E3 ligase samples are available that offer immediate entry points for high‑impact structural and functional studies
access to cutting‑edge cryo‑EM/ET, mass spectrometry, imaging facilities, and service platforms at the Vienna BioCenter
a stimulating, open, and international research environment with strong support for career development; all coming with Vienna, one of the most liveable cities on this planet
#J-18808-Ljbffr
About the Place The IMP is part of the Vienna BioCenter, one of the world's leading life science campuses. It offers access to state-of-the-art cryo-EM infrastructure, proteomics, imaging, high performance computing and a vibrant interdisciplinary community. Our lab is part of the "Ubiquitin & Friends" network, a local proteostasis hub comprising more than 100 researchers across twelve Vienna BioCenter groups, fostering collaboration and innovation.
Your Profile We are looking for a curious, ambitious, and collaborative scientist with …
a completed PhD in structural biology, biochemistry, or chemical biology
hands‑on experience in cryo‑EM data collection and processing (single‑particle analysis and/or cryo‑ET), in vitro reconstitution of multi‑protein assemblies and/or familiarity with RNA, DNA or lipid biochemistry
a publication record with first‑author contributions demonstrating this expertise
a strong interest in ubiquitin biology, innate immunity or proteostasis networks
What We Offer We offer a 3‑year postdoctoral position, with possibility of extension, and a few extras …
a unique head start: multiple E3 ligase samples are available that offer immediate entry points for high‑impact structural and functional studies
access to cutting‑edge cryo‑EM/ET, mass spectrometry, imaging facilities, and service platforms at the Vienna BioCenter
a stimulating, open, and international research environment with strong support for career development; all coming with Vienna, one of the most liveable cities on this planet
#J-18808-Ljbffr
Kontaktdaten:
IMP - Research Institute of Molecular Pathology Recruiting-Team
