As part of a three-year PhD project, the successful candidate will investigate the protective and antitumoral effects of cannabidiol (CBD) in combination with radiotherapy in glioblastoma. The project focuses on how CBD affects tumor radiosensitivity, the tumor microenvironment, and, in particular the function and integrity of healthy brain tissue.
Aufgaben
- You will work with established glioblastoma mouse models and clinically relevant irradiation protocols
- A particular focus will be the functional characterization of the brain using electrophysiological approaches, including LTP recordings, extracellular field potential recordings and whole-cell patch-clamp, as well as live-cell and high-resolution imaging, including calcium imaging and optoacoustic imaging. Complementary morphological, molecular and immunological analyses will be performed to link functional alterations to their structural and molecular mechanisms.
- A central objective is the quantitative integration of electrophysiological and imaging data to elucidate the mechanisms underlying radiation-induced neuronal damage and potential CBD-mediated neuroprotection.
Profil
- We are looking for a highly motivated candidate with a Master’s degree in neuroscience, biology, biophysics, physiology, pharmacology or a related discipline, with a strong interest in interdisciplinary experimental research.
- practical experience in electrophysiology, especially patch-clamp or extracellular recordings
- experience with live-cell, calcium or confocal imaging and quantitative image analysis
- an interest in neuronal plasticity and functional alterations of the brain
- willingness to learn and apply new techniques, including optoacoustic imaging and experimental animal procedures.
- Experience in glioblastoma, cancer or radiation research is advantageous but not essential. Most importantly, we are looking for experimental skills, scientific curiosity, independence and the ability to integrate electrophysiological, imaging and molecular findings into a coherent mechanistic framework
Benefits
- A three-year PhD project (60% part-time)
- EGYM well pass, corporate benefits and discounts (e.g. Käfer), cafeteria, sports and cultural offers, company bike
- Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as the subway, S-Bahn or tram
- Company pension plan through the Federal and State Pension Institute (VBL)
- Self-realization through a varied and technically demanding job with interdisciplinary cooperation between various departments of the TUM Klinikum
Kontakt
Gerhard Rammes
Klinik für Anästhesiologie und Intensivmedizin
089 4140 9839
Weitere Informationen
If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference.
Interview-related costs can, unfortunately, not be reimbursed.
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PhD Researcher (m/f/d) – Cannabidiol in radiotherapy in glioblastoma in München Arbeitgeber: Klinikum der Technischen Universität München (TUM Klinikum)
Als Physiotherapeut (m/w/d) in der stv. Teamleitung im Herzen Münchens profitieren Sie von einer wertschätzenden Arbeitskultur, die auf interprofessioneller Zusammenarbeit und kontinuierlicher Weiterbildung basiert. Wir bieten Ihnen nicht nur eine fundierte Einarbeitung, sondern auch die Möglichkeit, sich zur Teamleitung zu entwickeln, sowie attraktive Corporate Benefits wie den EGYM-Wellpass und Sportangebote. Genießen Sie die Vorzüge einer abwechslungsreichen Tätigkeit in einem dynamischen Umfeld mit hervorragender Anbindung an öffentliche Verkehrsmittel.
Kontaktdaten:
Klinikum der Technischen Universität München (TUM Klinikum) Recruiting-Team
