pWork Your Magic with us! /p /brpReady to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. /p /brpUnited As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. /p /brpWithin Global Drug Product Development, we are seeking a motivated bFormulation Development Scientist /b with a strong background in protein biologics. /p /brpIn this role, you will contribute to early-phase drug product development by designing and executing formulation, process development, stability, and administration‑simulation studies, as well as late‑phase formulation development activities. Your primary focus will be protein biologics, including monoclonal antibodies, fusion proteins, and antibody–drug conjugates. As the portfolio evolves, you will also have opportunities to contribute to formulation‑development activities for emerging modalities. /p /brpReporting to the Early‑Phase Parenteral Drug Product Development Manager, you will work closely with formulation, analytical, automation, and project‑team colleagues. Together, you will generate data‑driven recommendations that reduce CMC risks and support molecule progression. You will combine hands‑on formulation science with modern automation and digital technologies, contribute to the advancement of promising protein biologics, and gain exposure to evolving modalities and development approaches. /p /brh3Key Responsibilities /h3 /brul /brliDesign, plan, execute, interpret, and document phase‑appropriate drug product formulation, process development, stability, and administration‑simulation studies for protein biologics. /li /brliApply scientific knowledge of protein structure, stability, degradation pathways, and stabilization strategies to support formulation selection and development decisions, including early CMC risk‑reduction activities /li /brliCollaborate with analytical scientists to define characterization strategies, interpret analytical results, and perform selected hands‑on experiments, including differential scanning fluorimetry, dynamic light scattering, spectroscopic measurements, and stability assessments, as needed. /li /brliPartner with automation and robotics experts to execute and improve automated or high‑throughput formulation‑development workflows. /li /brliProvide scientific input to formulation‑development plans, project strategies, and technical discussions within cross‑functional project teams, and represent drug product development in CMC sub‑teams. /li /brliCommunicate study outcomes, technical risks, and recommendations clearly to colleagues and project stakeholders. /li /brliAuthor and review development reports and contribute to documentation supporting internal decisions, regulatory submissions, and responses. /li /brliIdentify and assess new technologies, analytical approaches, and digital tools; contribute to establishing formulation‑development capabilities for emerging modalities; and maintain high standards for data quality, laboratory safety, scientific documentation; share technical knowledge and support onboarding or development of colleagues where appropriate. /li /br /ul /brh3Required Qualifications /h3 /brul /brliPhD in pharmaceutical sciences, chemistry, pharmacy, biology, biotechnology, or a related field, with initial relevant industrial or postdoctoral experience preferred; or a master’s degree in a relevant discipline with at least five years of relevant experience in biologics formulation development or characterization. /li /brliStrong scientific understanding of protein structure, physical and chemical stability, degradation mechanisms, and formulation‑stabilization strategies. /li /brliHands‑on experience in the formulation development and/or physicochemical characterization of protein biologics, such as monoclonal antibodies, fusion proteins, or antibody–drug conjugates is a must. Exposure to the formulation development of emerging modalities, such as antibody–oligonucleotide conjugates is a plus. /li /brliExperience designing and interpreting development studies using Quality by Design principles, design of experiments, and statistical analysis. /li /brliFamiliarity with analytical techniques used to characterize biologic drug products is a must. Hands‑on experience with characterization techniques such as circular dichroism, FT‑IR, Raman spectroscopy, fluorescence spectroscopy, differential scanning fluorimetry, or dynamic light scattering is a plus. /li /brliAbility to evaluate data critically, solve technical problems, and translate results into scientifically sound recommendations. /li /brliAbility to work independently on assigned activities while seeking guidance for complex technical or strategic decisions. /li /brliStrong collaboration skills, the ability to work effectively across scientific disciplines in a dynamic project environment, and excellent written, verbal, and presentation skills in English. /li /brliExperience contributing to CMC development documentation and/or regulatory submissions is a plus /li /br /ul /brh3What we offer: /h3 /brpWe are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress! /p /br #J-18808-Ljbffr
Scientist - Drug Product Development - All Genders Arbeitgeber: Merck Healthcare
Als Principal Scientist in der Strukturbiologie bieten wir Ihnen die Möglichkeit, in einem innovativen und dynamischen Umfeld zu arbeiten, das Vielfalt und Inklusion schätzt. Unsere Unternehmenskultur fördert die persönliche und berufliche Entwicklung, während Sie an spannenden interdisziplinären Projekten mitarbeiten, die das Leben von Menschen weltweit bereichern. Genießen Sie die Vorteile eines kreativen Arbeitsumfelds, in dem Ihre Ideen geschätzt werden und Sie die Chance haben, als Mentor für aufstrebende Wissenschaftler zu wirken.