Head of In Vitro Pharmacology in Großmehring, München

Head of In Vitro PharmacologyProteros BiostructuresMunich, GermanyYour missionEstablish all in vitro pharmacology capabilities and processes required for integrated drug discovery programs.Define and lead the required design, execution, and analysis of cell-based assays to support hit identification, hit-to-lead, and lead optimization campaigns.Select, engineer, and characterize disease-relevant cell lines, including stable and transient transfection models.Provide strategic input into target selection and validation.Design strategies for high-throughput screening campaigns using advanced assay technologies (NanoBRET, NanoBiT, TR-FRET, AlphaScreen, luminescence, reporter gene activation, FLIPR and others).Apply molecular and cellular biology techniques (e.g., Western blot, qPCR, gene editing, siRNA knockdown, biomarker assays) to evaluate compound activity, efficacy, mechanism of action and pathway engagement.Ensure robust experimental design, reproducibility, and data quality while meeting project timelines.Lead and mentor a team of research associates and scientists to achieve operational and scientific excellence.Collaborate and communicate effectively within cross-functional drug discovery teams, including medicinal chemistry, biophysics, structural biology, protein sciences, and computational chemistry.Align scope, timelines and decision points for support of med chem optimization, and generate high-quality in vitro pharmacology data packages to support IND-enabling activities and candidate nomination decisions.Present scientific capabilities and findings to internal stakeholders and external partners.Lead implementation of automation, liquid handling systems, and high-throughput assay processing to enhance team productivity and scalability.Your profileRequiredPhD in Cellular Biology, Pharmacology, Chemical Biology or a related discipline.10+ years of industry experience in in vitro pharmacology within a small molecule drug discovery setting (biotech or pharmaceutical).Extensive expertise in cellular and molecular biology techniques.Proven track record of contributing to the progression of small molecule drug candidates from hit to candidate nomination.Hands-on experience with assay development for potency, efficacy, target engagement, selectivity, and mechanism of action of small molecules.Proficiency in mammalian cell culture (including establishing and maintaining transient and stable cell lines).Long-standing experience with liquid handling systems, automation, and high-throughput assay execution.Strong skills in data analysis, interpretation, and scientific communication.Demonstrated ability to manage multiple projects in a fast-paced, dynamic research environment.Strong leadership skills with experience managing research associates and scientists.Excellent organizational, written, and oral communication skills.Experience in one or more key disease areas, including oncology, immunology, neuroscience, or metabolic diseases.PreferredFamiliarity with CRO operating environment, including multi-client project management, resource planning, and client-facing scientific communication.Experience with targeted protein degradation modalities (PROTACs, molecular glues, bifunctional degraders).Knowledge of DMPK interface: protein binding, metabolic stability, and their impact on in vitro assay interpretation.Experience operating within an IND-enabling or GLP-compliant environment. #J-18808-Ljbffr