Responsibilities
- Develop and implement bioinformatics workflows for single-cell RNA-seq and spatial omics data analysis.
- Optimize and apply nextflow / nf-core pipelines for data processing and analysis.
- Integrate multi-omics datasets to derive meaningful biological insights.
- Perform quality control, normalization, clustering, and trajectory inference on single-cell datasets.
- Analyze spatial transcriptomics data to study tissue architecture and cellular interactions.
- Work on high-performance computing (HPC) environments, ensuring efficient and scalable data processing.
- Develop custom scripts and software tools to enhance analytical capabilities.
- Collaborate with wet-lab scientists to interpret results and refine experimental designs.
- Maintain well-documented, reproducible, and FAIR-compliant workflows.
Qualifications
Required Qualifications
- Ph.D. or M.Sc. in Bioinformatics, Computational Biology, Data Science, or a related field.
- Strong experience in single-cell transcriptomics (scRNA-seq, scATAC-seq, etc.) and/or spatial omics analysis.
- Proficiency in R and Python for bioinformatics and statistical analysis.
- Hands-on experience with nf-core pipelines and Nextflow.
- Experience working with high-performance computing (HPC) environments and cloud-based solutions.
- Familiarity with open-source bioinformatics tools for single-cell analysis (e.g., Seurat, Scanpy, Cell Ranger, Squidpy).
- Solid understanding of machine learning approaches applied to biological data.
- Ability to work both independently and as part of a collaborative, interdisciplinary team.
- Strong problem-solving skills and attention to detail.
Preferred Qualifications
- Experience with visualization techniques for single-cell and spatial omics data.
- Experience with multi-omics integration (e.g., single-cell RNA-seq + ATAC-seq / ChIP-seq).
- Familiarity with database management and workflow automation.
- Knowledge of statistical modeling and network-based analysis.
- Contributions to open-source bioinformatics projects.
Additional Information
Benefits:
- A stimulating research environment at the intersection of computational and experimental biology.
- Engage in high-impact research projects that contribute to advances in cancer treatment.
- Opportunities for professional development, co-authorship in scientific publications, and conference participation.
- Access to cutting-edge computational infrastructure and datasets.
- Competitive salary and benefits package.
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Kontaktperson:
Robert Bosch Centrum für Tumorerkrankungen HR Team