Chez Roche, vous pouvez être vous-même et être apprécié pour les qualités uniques que vous apportez. Notre culture encourage l'expression personnelle, le dialogue ouvert et les connexions authentiques, où vous êtes valorisé, accepté et respecté pour ce que vous êtes, vous permettant de prospérer tant personnellement que professionnellement. Voici comment nous visons à prévenir, arrêter et guérir les maladies et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Rejoignez Roche, où chaque voix compte.
La position
In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.
The Opportunity
Joining Small Molecule Research Discovery within Therapeutic Modalities, you will work within a highly engaged, cross-functional team bridging cell biology, automation, and multiple therapeutic areas. In this role, you drive innovation through strong commitment to lab science by developing the foundational cellular models that power our drug discovery pipeline.
Your key responsibilities include:
- Developing, optimizing, and validating robust cell-based functional assays—including complex 3D models—using technologies such as HTRF, AlphaLISA, Luminescence, and High-Content Imaging.
- Miniaturizing cellular assays into high-density plate formats (384-well and 1536-well plates), optimizing performance parameters such as Z’-factor and signal-to-background ratio.
- Maintaining, characterizing, and performing quality control on a wide range of mammalian cell lines, including primary cells, continuous lines, and induced pluripotent stem cells (iPSCs).
- Partnering closely with the High-Throughput Screening and Profiling team to seamlessly transfer new assays onto integrated robotic systems.
- Running routine cellular assays to generate high-quality data supporting structure-activity relationship (SAR) studies for portfolio projects.
- Analyzing complex screening datasets using modern scientific tools (e.g., Genedata Screener, Spotfire) and documenting workflows meticulously in Electronic Lab Notebooks (ELN).
- Serving as the primary cellular assay expert on multidisciplinary project teams, sharing insights across chemistry, High-Throughput Screening and Profiling, and therapeutic area groups.
Who You Are
You are a curious, highly motivated scientist who thrives on solving complex biological challenges. You bring a collaborative mindset, value diverse perspectives, and are eager to apply your expertise to discover life-changing treatments.
Qualifications and skills:
- Master’s degree in Cell Biology, Molecular Biology, or a closely related scientific discipline.
- 5+ years of relevant industry research experience focused on advanced cell culture and cell-based assay development.
- Demonstrated experience in miniaturizing assay workflows into 384- and 1536-well plate formats and utilizing automated liquid-handling systems.
- Strong proficiency in data analysis, statistical evaluation, and presenting scientific findings clearly to multidisciplinary teams.
- Fluency in English with strong interpersonal and communication skills.
- Flexibility and a resourceful problem-solving approach tailored to a dynamic lab environment.
- Nice to have: Hands-on experience with iPSC differentiation, 3D cellular models, or Design-of-Experiments (DoE) methodology.
Please be advised that this position is 100% lab-based.
Qui nous sommes
Un avenir plus sain nous pousse à innover. Ensemble, plus de 100 000 employés à travers le monde sont dédiés à faire progresser la science et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Nos efforts aboutissent à plus de 26 millions de personnes traitées avec nos médicaments et plus de 30 milliards de tests réalisés avec nos produits de Diagnostique. Nous nous encourageons mutuellement à explorer de nouvelles possibilités, à favoriser la créativité et à conserver nos grandes ambitions, afin de fournir des solutions de santé qui changent des vies et ont un impact mondial.
Construisons ensemble un avenir plus sain.
Roche est un employeur offrant l'équité en matière d'emploi.
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Research Associate In Cellular Assay Development Arbeitgeber: Roche Holding AG
Roche ist ein hervorragender Arbeitgeber, der eine inklusive und unterstützende Arbeitskultur fördert, in der jeder Mitarbeiter geschätzt und respektiert wird. Als Biostatistiker (m/w/d) in unserem R&D-Team hast du die Möglichkeit, an innovativen Projekten zu arbeiten, die einen direkten Einfluss auf die Gesundheitsversorgung haben. Wir bieten kontinuierliche Weiterbildung, enge Zusammenarbeit mit interdisziplinären Teams und die Chance, deine Fähigkeiten in einem dynamischen Umfeld weiterzuentwickeln.
