Interim Pharmaceutical Crystallization & Solid-State Consultant (f/m/d)
We are currently seeking an experienced Senior Pharmaceutical Crystallization & Solid-State Consultant to support a leading pharmaceutical organization in the review, optimization, and scale-up of small molecule crystallization and solid-state development activities.
Key Responsibilities:
- Review and assess crystallization and co-crystal development activities performed by external development partners and CDMOs.
- Provide expert guidance on the development, optimization, and scale-up of robust pharmaceutical crystallization processes.
- Support troubleshooting activities related to crystal form selection, morphology, yield, and downstream processability.
- Advise on crystallization strategies, experimental design, process parameters, and analytical approaches.
- Assess scalability from laboratory to pilot and commercial manufacturing scale, identifying critical technical risks.
- Evaluate the impact of solid-state and particle properties on API processing and drug product performance.
- Provide independent technical recommendations and support strategic development decisions.
Required Expertise:
- MSc or PhD in Chemistry, Physical Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related discipline.
- Extensive industry experience in small molecule pharmaceutical crystallization, solid-state development, and/or particle engineering.
- Proven track record in the successful development and scale-up of crystallization processes.
- Strong expertise in pharmaceutical solid-state and particle characterization techniques.
- Experience with pharmaceutical co-crystals is highly desirable.
- Understanding of the relationship between API solid-state properties, downstream processing, and formulation performance.
- Previous experience working with or managing external CDMOs is an advantage.
- Knowledge of formulation development for poorly soluble small molecules is a plus.
Contract: Freelance / Interim
Start: ASAP
Duration: at least 6 months
Where: Remote
