Postdoc - Cancer Research (m/f/d)

Full- or part-time | temporary (48 months) | Klinik und Poliklinik für Innere Medizin II

Dissecting genomic and post-transcriptional processes and their dynamics in pancreatitis and pancreatic cancer.

Our research focuses on genomic and post-transcriptional processes that facilitate tumor evolution, tumor heterogeneity, metastasis, and drug resistance in cancer. We aim to understand the dynamics of genome editing on the DNA and RNA level, cellular signaling, and their impact on the microenvironment in the context of inflammatory diseases and cancer. We employ cutting-edge computational biology methods to identify genomic aberrations, mutations, and post-transcriptional processes. In addition, we aim to verify those findings functionally and mechanistically with various molecular biology assays using a broad range of in vitro and in vivo platforms, including genetically engineered 2D/3D cell-, organoid- and mouse models, and human specimens.

Our overall goal is to gain a better mechanistic understanding that can be leveraged to identify novel treatment approaches to improve the clinical outcome in patients with inflammatory diseases and cancer. Our lab is currently growing to establish versatile cancer genomics, proteomics, and cell biology platforms to make an impact on the development of novel therapies.

• We are looking for a talented scientist driven by the desire to make a relevant contribution to the pancreatitis and pancreatic cancer field by discovering significant findings in the lab
• Knowledge of cancer genomics, proteomics, single-cell RNAseq, spatial transcriptomics, and molecular cell biology is recommended
• Prior research experience in computational platforms: scanpy & scverse, spatial omics data structure: “spatialdata“, spatial omics analysis framework “squidpy-, NCEM, SNV, CNA, phylogenies using Mutect2, ASCAT, Battenberg, GRIDSS2, DPclust, Mutational/CNA signature extraction, RNA editing deep learning framework
• The ability to drive projects with a high degree of excitement is encouraged
• The position requires a doctoral degree in a relevant field, such as computational science, bioinformatics, or biology

• A varied and professionally demanding position in a state-of-the-art working environment
• Comprehensive on-the-job training provided by experienced and qualified colleagues
• The opportunity to take part in internal and external professional development courses
• A good work-life balance with flexitime and 38.5 weekly working hours, 30 holidays per year, and options for childcare
• An opportunity to work in two exciting research institutions: at the Klinikum rechts der Isar in the city centre of Munich on Max -Weber-Platz and at the Helmholtz Center in Neuherberg, both places with good access to public transport systems
• You may be entitled to a special allowance to make up for the higher cost of living in Munich (“Ballungsraumzulage-)
• Employee saving schemes and company pension system
• Employee perks, such as discounts, canteen, sports activities or cultural activities
• Individual support offered by our conflict management or clinical pastoral care
• Health support such as health check-ups or vaccinations