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- Aufgaben: Join our lab to explore microtubule dynamics in cell biology and tissue morphogenesis.
- Arbeitgeber: Be part of UKM, a leader in healthcare research with a strong social mission.
- Mitarbeitervorteile: Enjoy a part-time position with a competitive salary and the chance to work on innovative projects.
- Warum dieser Job: Dive into cutting-edge research that impacts healthcare while collaborating with passionate scientists.
- Gewünschte Qualifikationen: Ideal candidates have a background in fly genetics, microscopy, or biophysics and strong communication skills.
- Andere Informationen: Apply by 05.03.2025 with your motivation letter and research interests.
Das voraussichtliche Gehalt liegt zwischen 30000 - 42000 € pro Jahr.
PhD Student (gn*) Developmental and Cell Biology
Fixed-term of 3 years | Part-time with 65% | Salary grade TV-L E13 | Institute of Cell Biology
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Institute of Cell Biology in mechanobiology – ideally with you on board!
The lab of Dr. Maja Matis investigates the spatio-temporal dynamics of microtubule cytoskeleton organization and force regulation during tissue morphogenesis in Drosophila. Specifically, we aim to understand how cells regulate and coordinate cytoskeletal forces to control cell architecture and collective cell behaviors. Our research combines innovative optical and chemical tools with classical genetic techniques and advanced image analysis to study cytoskeletal force dynamics quantitatively. A key focus is understanding how microtubules contribute to morphogenetic tissue rearrangements and wound healing processes.
SPECIFIC RESEARCH PROJECT:
Microtubules are indispensable structural elements in living systems. Their unique mechanical properties play a central role in many cellular functions, including cell division, motility, intracellular transport, and the generation of various cellular architectures. Their mechanical resilience is provided by their structure, making them the most rigid intracellular cytoskeletal filaments. In this project, we will investigate the molecular mechanisms that regulate the biophysical properties of microtubules. Features of individual microtubules largely differ depending on (i) expression of different α- and β-tubulin isoforms and (ii) post-translational modifications (PTMs) of individual tubulin monomers. However, despite their importance, the role of different tubulin isoforms and PTMs in cell and tissue mechanics has, to date, not been addressed in vivo. To identify the “mechanical” tubulin code, we will analyze the expression pattern of tubulin isoforms, address their role in regulating microtubule properties, study PTMs of non-centrosomal microtubules and test their role in cell and tissue remodeling when they are exposed to increased mechanical stress.
REQUIREMENTS:
- Motivated PhD student with a background in fly genetics, light microscopy, cell biology or biophysics
- Good English and communication skills
- Interest in different scientific fields, are needed due to the interdisciplinary nature of the project and the group
Apply now via our career portal until 05.03.2025 including:
- Letter of motivation/statement of research interests
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PhD Student (gn*) Developmental and Cell Biology Arbeitgeber: UKM
Kontaktperson:
UKM HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: PhD Student (gn*) Developmental and Cell Biology
✨Tip Number 1
Familiarize yourself with the specific research focus of Dr. Maja Matis' lab. Understanding the spatio-temporal dynamics of microtubule cytoskeleton organization will help you articulate your interest and how your background aligns with their work.
✨Tip Number 2
Highlight any relevant experience you have with fly genetics or light microscopy in your discussions. This will demonstrate your hands-on skills and show that you can contribute to the lab's interdisciplinary approach.
✨Tip Number 3
Engage with current literature on microtubule mechanics and post-translational modifications. Being well-versed in recent findings will allow you to discuss innovative ideas during interviews and show your commitment to the field.
✨Tip Number 4
Network with current or former PhD students from the Institute of Cell Biology. They can provide insights into the lab culture and expectations, which can be invaluable for tailoring your approach when applying.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: PhD Student (gn*) Developmental and Cell Biology
Tipps für deine Bewerbung 🫡
Understand the Research Focus: Familiarize yourself with the specific research project on microtubules and their role in cell mechanics. Highlight your relevant experience in fly genetics, light microscopy, or biophysics in your application.
Craft a Strong Letter of Motivation: Your letter should clearly express your motivation for applying to this PhD position. Discuss your research interests and how they align with the lab's focus on mechanobiology and cytoskeletal dynamics.
Showcase Your Skills: Emphasize your skills in communication and interdisciplinary collaboration. Mention any relevant projects or experiences that demonstrate your ability to work in diverse scientific fields.
Proofread Your Application: Before submitting, carefully proofread your application materials. Ensure that your CV, letter of motivation, and any other documents are free of errors and clearly present your qualifications.
Wie du dich auf ein Vorstellungsgespräch bei UKM vorbereitest
✨Show Your Passion for Developmental Biology
Make sure to express your enthusiasm for developmental and cell biology during the interview. Discuss specific aspects of the research project that excite you, especially regarding microtubule dynamics and their role in tissue morphogenesis.
✨Highlight Relevant Experience
Be prepared to talk about your background in fly genetics, light microscopy, or biophysics. Share specific examples of your previous research or projects that relate to the requirements of the position, emphasizing any hands-on experience you have with relevant techniques.
✨Demonstrate Interdisciplinary Knowledge
Since the project is interdisciplinary, showcase your interest and knowledge in various scientific fields. Be ready to discuss how different areas of science can intersect and contribute to understanding microtubule mechanics and cellular functions.
✨Prepare Thoughtful Questions
Come prepared with insightful questions about the lab's research focus, ongoing projects, and future directions. This shows your genuine interest in the work being done and helps you assess if the lab environment aligns with your academic goals.
