Postdoctoral researcher (m/f/d) – life sciences, Institute of Laboratory Medicine, Clinical Chemistr

Postdoctoral researcher (m/f/d) – life sciences

Institute of Laboratory Medicine, Clinical Chemistry and

Molecular Diagnostics

40 hours / week, temporary contract with possibility of extension up to 5 years

Salary scale of the University Hospital Leipzig (UKL)

Earliest start: 01.12.2024 (or immediately, if possible)

Closing date for applications: 31.10.2024

Research Area: We are seeking a strong postdoctoral researcher. The successful candidate will investigate a novel molecular switch controlling thrombo-inflammation based on the interaction of TF (F3, tissue factor) and interferon-alpha receptor subunit 1 (IFNAR1) using cell biological, protein biochemical and in vivo approaches. Thrombo-inflammation is a central mechanism of tissue injury in many diseases, including vascular, metabolic and cancer, yet effective therapies are lacking. We have identified a novel molecular switch that controls thrombo-inflammation, which will be characterized in different disease models and in humans to find new diagnostic and therapeutic approaches.

Scope of the position: The successful candidate will study the regulation of TF-IFNAR1 interaction and intracellular signaling in vitro and in vivo . We will use advanced in vitro methods, various omics approaches and innovative mouse models. Detailed structure-function analyses based on newly generated structural data will be performed to define the molecular mechanisms as a basis for innovative diagnostic and therapeutic approaches. Recent publications from the Isermann lab include Zimmermann (2024), KidInt, PMID: 39089576; Manoharan (2024), Immunity, PMID: 38141610; Rana (2024), KidInt, PMID: 37774921; Al-Dabet (2022), Nat Communication, PMID: 36030260; Gadi (2021), Circ Research, PMID: 33353373; Kohli (2021), Blood, PMID: 32870264. For more information about our research profile, see

Requirements: Applicants must have a Ph.D. in a biomedical field (biology, biochemistry, biotechnology, physiology, or equivalent), a strong publication record that will allow them to obtain independent funding, and prior experience with at least some of the methodological topics of this project: work with mice, molecular biology, protein biochemistry, flow cytometry, microscopy, immunohistochemistry. Experience in thrombosis & hemostasis and/or thrombo-inflammation is desirable. The position will be paid according to the German civil service scale.

Research Environment: The successful candidate will join a highly collaborative institute and will have access to state-of-the-art facilities for molecular biology, protein biochemistry, biophysics, pharmacology, mouse genetics, and the latest imaging applications including light sheet and FRET microscopy. The position will be embedded in the ERC-funded project TameThiFlame. The Medical Faculty is located within the University of Leipzig with direct access to numerous research facilities of the University and extramural institutes such as the Helmholtz, Max Planck and Fraunhofer Institutes. All of these institutes are within walking distance of the medical campus, providing a very supportive environment for young students to pursue their doctoral studies. The University of Leipzig embraces diversity and seeks candidates who will foster a climate that attracts all students, staff and faculty.

Please apply by October 31, 2024 for full consideration. Applicants should submit a curriculum vitae, including a current list of publications, a research statement, and the names and contact information of three references. Applications should be submitted electronically in PDF format to

Contact:

Prof. Dr. med. Berend Isermann
Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostic
Faculty of Medicine, Leipzig University, Paul-List Straße 13/15, 04103 Leipzig, Germany

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