PhD Position in Molecular Mechanisms of Human Infertility

is available immediately at the AG Krigeva in the Department of Gynecological Endocrinology and Fertility Disorders at the University Women's Hospital of Heidelberg University.Job-ID:V Field of application:Klinik für Gynäkologische Endokrinologie und FertilitätsstörungenLocation:HeidelbergJob Category:Science and teachingWorking hours:full-time (100 %)Published: Limitation:Temporary (3 years)Contract:TV-LYour tasksInfertility affects millions worldwide, yet in many cases the genetic basis remains unknown. Instead of focusing solely on gene-by-gene sequencing, this project aims to uncover the shared molecular mechanisms that drive infertility and open the way for new diagnostics and therapies.Our recent findings show that infertile individuals share phenotypes associated with genotoxic stress and altered androgen receptor (AR) expression. In this PhD project, you will investigate how the cGAS–STING signaling pathway translates genome instability into pathological changes in gonadal tissues.

You will study its role in autophagy regulation, innate immune responses, telomere maintenance, and its interaction with AR signaling in the context of reproductive health.We are looking for a highly motivated PhD candidate with a strong interest in reproductive biology, molecular genetics, or cell signaling. You will receive advanced training in molecular and cellular biology, reproductive genetics, and mechanistic pathway analysis, and contribute to a project with direct relevance for future diagnostic tools and therapeutic approaches in human reproductive medicine.You will cover the entire spectrum of wet lab experimental work with the "state of the art" technicsDNA, RNA, Protein work: isolation and analysis with PCR, qPCR, Western blot Immunofluorescence, microscopy, histology Cell culture Develope new methods like gonadal organoids or work with primary patient's cells Specific data entry, documentation, and archiving workYour profileSuccessfully completed a Master's degree in Cell Biology, Developmental Biology, Genetics or Molecular BiologyExperience with cell culture and wet lab techniques, including DNA/RNA/protein analysesGood command of the English languageStrong teamwork skills, reliability, and flexibilityHigh level of commitment and independent workIT skillsWe offerGoal-oriented, individual training and development opportunitiesWorking with the latest techniques / technical equipmentFlexible working hours within the framework of flexitimePossibility of doctoratePossibility to publish scientifically is offered and supportedRegular team meetingsCollectively agreed remuneration (TV-L E13), attractive company pension scheme (VBL)30 days vacationSustainable travel: job ticketFamily-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of careWide range of health, prevention and sports offersContact & ApplicationFor further information please contact Dr. Maria Krivega via e-mail.Interested?Applications will be accepted until via e-mail or online.Klinik für Gynäkologische Endokrinologie und FertilitätsstörungenDr.

Maria Krivega – group leaderIm Neuenheimer Feld 44069120 HeidelbergNote: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.The UKHD embraces diversity and values diversity.Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance.

If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.Classification is based on qualifications and personal requirements. The salary (gross) is for a full-time position and does not include the annual bonus or other allowances.