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- Aufgaben: Join our research team to explore the role of TSC22D4 in liver fibrosis.
- Arbeitgeber: Be part of Heidelberg University Hospital's innovative Joint IDC Translational Diabetes Program.
- Mitarbeitervorteile: Gain hands-on experience in cutting-edge research with a supportive team environment.
- Warum dieser Job: Contribute to impactful research on metabolic disorders and enhance your scientific skills.
- Gewünschte Qualifikationen: MSc in biological sciences with a focus on molecular and cellular biology required.
- Andere Informationen: Applications accepted until 31.01.2025; contact Dr. Bilgen Ekim for more info.
Das voraussichtliche Gehalt liegt zwischen 36000 - 60000 € pro Jahr.
wanted at the Department of Endocrinology and Metabolism in our lab at the Joint Heidelberg IDC Translational Diabetes Program.
We are excited to announce an opening for a PhD student to join our dynamic research team at Joint Heidelberg-IDC Translational Diabetes Program at Heidelberg University Hospital. If you are passionate about unraveling the molecular mechanisms underlying metabolic disorders and eager to contribute to cutting-edge advancements in translational research, we want to hear from you!
Your tasks
TSC22D4 is an evolutionarily conserved protein with a long stretch of intrinsically disordered region (IDR) which contains multiple phosphorylation sites. Patients with type 2 diabetes and liver fibrosis have elevated TSC22D4 protein levels in their liver. In this project, you will investigate whether phosphorylation of TSC22D4 contributes to liver fibrosis by performing experiments both in cell culture and in mouse models. The tasks will involve overexpressing wild type, phospho-defective, and phospho-mimetic TSC22D4 mutants in primary hepatocytes or in mouse livers to address whether TSC22D4 phosphorylation plays a role in apoptosis, inflammation, and liver injury. The techniques for these measurements will mostly include RNA and protein extraction from the cells or the liver tissue, qPCR analysis, western blotting, ELISA, and immunohistochemical stainings.
Your Profile
- A highly motivated and hardworking student with a MSc degree in biological sciences and a strong academic background in molecular and cellular biology.
- Demonstrated interest and experience in metabolism research including cell culture work and mouse models as well as excellent communication and teamwork skills.
About us
For further information please contact Dr. Bilgen Ekim via email.
Interested?
Applications will be accepted until 31.01.2025 via e-mail .
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PhD Student (m/f/d) Arbeitgeber: Universitätsklinikum Heidelberg
Kontaktperson:
Universitätsklinikum Heidelberg HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: PhD Student (m/f/d)
✨Tip Number 1
Make sure to familiarize yourself with the latest research in metabolic disorders, particularly focusing on TSC22D4. This will not only help you understand the context of your potential work but also allow you to engage in meaningful discussions during interviews.
✨Tip Number 2
Network with current PhD students or researchers in the field of endocrinology and metabolism. They can provide insights into the lab's culture and expectations, which can be invaluable when preparing for your application.
✨Tip Number 3
Prepare to discuss your previous research experiences in detail, especially those related to cell culture and mouse models. Being able to articulate your hands-on skills and how they relate to the project will set you apart from other candidates.
✨Tip Number 4
Reach out to Dr. Bilgen Ekim with thoughtful questions about the research program. This shows your genuine interest and can help you make a positive impression before you even apply.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: PhD Student (m/f/d)
Tipps für deine Bewerbung 🫡
Understand the Research Focus: Familiarize yourself with the research being conducted at the Joint Heidelberg IDC Translational Diabetes Program. Highlight your understanding of metabolic disorders and how your background aligns with their focus on TSC22D4 and liver fibrosis.
Tailor Your CV: Ensure your CV emphasizes your MSc degree in biological sciences, relevant coursework, and any hands-on experience with cell culture and mouse models. Include specific projects or research that demonstrate your skills in molecular and cellular biology.
Craft a Compelling Cover Letter: Write a cover letter that showcases your passion for metabolism research and your motivation to contribute to the team. Mention any relevant experiences and how they have prepared you for this PhD position.
Follow Application Instructions: Make sure to send your application via email as specified in the job description. Double-check that all required documents are attached and that your email is professional and concise.
Wie du dich auf ein Vorstellungsgespräch bei Universitätsklinikum Heidelberg vorbereitest
✨Show Your Passion for Research
Make sure to express your enthusiasm for unraveling molecular mechanisms, especially in the context of metabolic disorders. Share any relevant experiences or projects that highlight your dedication to this field.
✨Demonstrate Technical Skills
Be prepared to discuss your experience with techniques mentioned in the job description, such as RNA and protein extraction, qPCR, western blotting, and ELISA. Providing specific examples of how you've used these methods in past research will strengthen your application.
✨Highlight Teamwork and Communication
Since teamwork is emphasized, be ready to share examples of successful collaborations in your previous work. Discuss how you effectively communicated with team members and contributed to group projects.
✨Prepare Questions for the Interviewer
Show your interest in the lab and the research by preparing thoughtful questions. Ask about ongoing projects, the lab's approach to research, or opportunities for professional development within the team.
