PhD Student Biology - Ageing (m/f/d)- Universitätsklinikum Münster

PhD Student (gn*) Biological Sciences

Fixed-term of 3 years | Part-time with 65 % | Salary according to TV-L E13 | Institute for Experimental Pathology | Job ID: 10520

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.

To meet our high standards every day, we are looking forward to your scientific expertise at the Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster – ideally with you on board!

Project Title

Altered production, dynamics, and function of neutrophils are hallmarks of inflammageing.

The Institute And Project

The Institute for Experimental Pathology is led by Oliver Soehnlein. His work focuses on the importance of neutrophils in acute and chronic inflammation (Soehnlein et al., Sci Transl Med, 2011; Ferraro et al., JACC, 2019; Silvestre-Roig et al., Nature, 2019; Schumski et al., Circulation, 2021). Central to the group\’s mechanistic understanding of how neutrophils promote chronic, sterile inflammation is its interplay with antigen presenting cells, predominantly macrophages (Soehnlein & Lindbom, Nat Rev Immunol, 2010; Soehnlein et al., Nat Rev Immunol, 2017; Soehnlein & Libby, Nat Rev Drug Discov, 2021). It is a key feature of the group\’s work to unveil thus far unknown mechanistic details which are then translated towards innovative preclinical intervention strategies (Alard et al., Sci Transl Med, 2015; Silvestre-Roig et al., Nature, 2019), some of which have been patented. In this project, altered mechanisms of granulopoiesis and dysregulated neutrophil functions in ageing will be investigated. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics. The project is embedded in national and international consortia on neutrophils and inflammation and funded by the Else Kröner-Fresenius Stiftung.

Your Tasks

• Design and conduct experiments utilizing state-of-the-art approaches such as:
• Animal models of neutrophil biology and ageing

• Flow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometry
• Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry
• Biochemical assays for cytokines and other inflammatory mediators

What we expect:

• MSc degree in Biological Sciences
• Strong background in immunology and/or ageing biology
• Expertise in one or more of the following areas:

• Flow cytometry-based phenotyping and sorting
• Immunofluorescence microscopy and histopathological evaluation
• Statistical programming languages like R or Python

What we offer:

• Competitive salary according to TV-L E13 scale, initially limited to three years
• Comprehensive benefits package including health insurance, pension plan, and family support services
• Access to world-class infrastructure, equipment, and resources
• Opportunities for professional growth, networking, and international collaboration
• Supportive environment fostering creativity, innovation, and interdisciplinary exchange

Benefits

• Exciting Projects
• Professional Development and Training
• Interdisciplinary Collaboration
• Part of Research Innovation
• Additional Benefits

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