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- Aufgaben: Join our lab to explore microtubule dynamics in cell biology and tissue morphogenesis.
- Arbeitgeber: Be part of UKM, a leader in healthcare research with a strong social mission.
- Mitarbeitervorteile: Enjoy a part-time position with a competitive salary and the chance to work on innovative projects.
- Warum dieser Job: Dive into cutting-edge research that impacts healthcare and contributes to scientific advancements.
- Gewünschte Qualifikationen: Seeking motivated PhD students with backgrounds in genetics, microscopy, or biophysics.
- Andere Informationen: Apply by 05.03.2025 with your motivation letter and research interests.
Das voraussichtliche Gehalt liegt zwischen 30000 - 42000 € pro Jahr.
PhD Student (gn*) Developmental and Cell Biology
Fixed-term of 3 years | Part-time with 65% | Salary grade TV-L E13 | Institute of Cell Biology
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Institute of Cell Biology in mechanobiology – ideally with you on board!
The lab of Dr. Maja Matis investigates the spatio-temporal dynamics of microtubule cytoskeleton organization and force regulation during tissue morphogenesis in Drosophila. Specifically, we aim to understand how cells regulate and coordinate cytoskeletal forces to control cell architecture and collective cell behaviors. Our research combines innovative optical and chemical tools with classical genetic techniques and advanced image analysis to study cytoskeletal force dynamics quantitatively. A key focus is understanding how microtubules contribute to morphogenetic tissue rearrangements and wound healing processes.
SPECIFIC RESEARCH PROJECT:
Microtubules are indispensable structural elements in living systems. Their unique mechanical properties play a central role in many cellular functions, including cell division, motility, intracellular transport, and the generation of various cellular architectures. Their mechanical resilience is provided by their structure, making them the most rigid intracellular cytoskeletal filaments. In this project, we will investigate the molecular mechanisms that regulate the biophysical properties of microtubules. Features of individual microtubules largely differ depending on (i) expression of different α- and β-tubulin isoforms and (ii) post-translational modifications (PTMs) of individual tubulin monomers. However, despite their importance, the role of different tubulin isoforms and PTMs in cell and tissue mechanics has, to date, not been addressed in vivo. To identify the “mechanical” tubulin code, we will analyze the expression pattern of tubulin isoforms, address their role in regulating microtubule properties, study PTMs of non-centrosomal microtubules and test their role in cell and tissue remodeling when they are exposed to increased mechanical stress.
REQUIREMENTS:
- Motivated PhD student with a background in fly genetics, light microscopy, cell biology or biophysics
- Good English and communication skills
- Interest in different scientific fields, are needed due to the interdisciplinary nature of the project and the group
Apply now via our career portal until 05.03.2025 including:
- Letter of motivation/statement of research interests
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PhD Student (gn*) Developmental and Cell Biology Arbeitgeber: Universitätsklinikum Münster
Kontaktperson:
Universitätsklinikum Münster HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: PhD Student (gn*) Developmental and Cell Biology
✨Tip Number 1
Familiarize yourself with the latest research in mechanobiology and microtubule dynamics. This will not only help you understand the lab's focus but also allow you to engage in meaningful discussions during the interview.
✨Tip Number 2
Connect with current or former PhD students from the Institute of Cell Biology. They can provide insights into the lab culture and expectations, which can be invaluable for your application and interview preparation.
✨Tip Number 3
Showcase any relevant experience you have with light microscopy or fly genetics in your conversations. Highlighting practical skills can set you apart and demonstrate your readiness for the research project.
✨Tip Number 4
Prepare thoughtful questions about the research project and the lab's future directions. This shows your genuine interest and enthusiasm for the position, making a positive impression on the selection committee.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: PhD Student (gn*) Developmental and Cell Biology
Tipps für deine Bewerbung 🫡
Understand the Research Focus: Familiarize yourself with the specific research project on microtubules and their mechanical properties. Highlight your relevant experience in fly genetics, light microscopy, or cell biology in your application.
Craft a Strong Letter of Motivation: Your letter should clearly express your motivation for applying to this PhD position. Discuss your research interests and how they align with the lab's focus on mechanobiology and cytoskeletal dynamics.
Showcase Your Skills: Emphasize your background in relevant scientific fields and any interdisciplinary experiences. Good communication skills are essential, so mention any experiences that demonstrate your ability to collaborate and communicate effectively.
Review and Submit: Before submitting your application, double-check all documents for completeness and accuracy. Ensure that your CV and letter of motivation are tailored to the job description and highlight your qualifications.
Wie du dich auf ein Vorstellungsgespräch bei Universitätsklinikum Münster vorbereitest
✨Show Your Passion for Developmental Biology
Make sure to express your enthusiasm for developmental and cell biology during the interview. Discuss specific aspects of the research project that excite you, such as the role of microtubules in tissue morphogenesis or wound healing processes.
✨Highlight Relevant Experience
Be prepared to talk about your background in fly genetics, light microscopy, or biophysics. Share specific examples of your previous research or projects that relate to the lab's focus on mechanobiology and cytoskeletal dynamics.
✨Demonstrate Interdisciplinary Interest
Since the project is interdisciplinary, show your interest in various scientific fields. Discuss how your diverse knowledge can contribute to the research and how you are eager to learn from other disciplines within the team.
✨Prepare Thoughtful Questions
Come with insightful questions about the lab's research direction, the methodologies used, or potential challenges in the project. This shows your genuine interest and helps you understand if the lab is the right fit for you.
