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- Aufgaben: Join our lab to explore the role of SMYD1 in heart regeneration using zebrafish and human cells.
- Arbeitgeber: Be part of a cutting-edge Molecular Cardiology lab focused on innovative cardiac research.
- Mitarbeitervorteile: Enjoy competitive pay, health promotion, and extensive training opportunities in a supportive environment.
- Warum dieser Job: Work on impactful research that could lead to new therapies for heart injuries in a collaborative team.
- Gewünschte Qualifikationen: Master’s degree in biology, biochemistry, or molecular medicine; strong communication skills; team player.
- Andere Informationen: Experience advanced techniques like CRISPR/Cas9 and high-resolution microscopy in a dynamic research setting.
Das voraussichtliche Gehalt liegt zwischen 36000 - 60000 € pro Jahr.
The Molecular Cardiology lab (PI: Prof. Dr. Steffen Just; in the Department of Internal Medicine II (Medical Director: Prof. Dr. Wolfgang Rottbauer) is currently looking for a PhD student (m/f/d) to study the molecular and epigenetic role of SMYD1 in sarcomeric renewal and regeneration in zebrafish and mammalian cardiomyocytes.
Due to our recent findings on the important role of methyltransferase SMYD1 on the methylation of sarcomeric Myosin, its assembly and homeostasis during cardiac development (Diofano et al., 2024), we will now focus this research project on the impact of SMYD1 on (1) Myosin methylation, cardiomyocyte de-dedifferentiation, sarcomeric breakdown, and functional cardiomyocyte re-differentiation during the regeneration of the adult zebrafish heart. Secondly, we will aim to (2) translate our recent zebrafish SMYD1 findings into the mammalian/human system by investigating the role of SMYD1 on MYOSIN methylation, sarcomeric assembly, and cardiomyocyte function in human iPSC-derived cardiomyocytes. The long-term goal of this project is to foster regenerative strategies as therapeutic options for acute or chronic myocardial injury.
The position offers the opportunity to work on a dynamic and innovative project employing cutting-edge technologies. These include in vitro studies (iPSC-derived cardiomyocytes) and in vivo (zebrafish) functional genomics. Advanced methods such as CRISPR/Cas9 gene editing, transgenesis, molecular biology, biochemistry, and high-resolution microscopy will be key components of the research. Additionally, omics-based approaches, such as transcriptomics, proteomics, and interactomics, will be used to generate comprehensive datasets. This research will focus on analyzing mutant zebrafish and human cardiomyocyte cell lines to explore molecular pathways involved in cardiac development, regeneration, and aging.
The successful candidate will join a collaborative, international research environment supported by state-of-the-art facilities. The role provides exceptional training opportunities, not only in technical and experimental methodologies but also in scientific communication and career development.
- a Master’s degree in biology, biochemistry, or molecular medicine
- a highly motivated, enthusiastic, and efficient researcher
- experience in molecular and cellular biology
- excellent communication skills in spoken and written English
- capability of working in a team as well as independently
We offer:
- the opportunity to work in a dynamic and highly motivated team of biologists and physicians
- an interesting research project in a stimulating and competitive field of science
- payment according to the collective Agreement TV-L
- a workplace health promotion
- numerous training and continuing education opportunities
- support concerning the compatibility of job and family
Are you interested? To apply, please send your application to:
E-Mail:
#J-18808-Ljbffr
a PhD student (m/f/d) Arbeitgeber: Universitätsklinikum Ulm
Kontaktperson:
Universitätsklinikum Ulm HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: a PhD student (m/f/d)
✨Tip Number 1
Familiarize yourself with the latest research on SMYD1 and its role in cardiac development. This will not only help you understand the project better but also allow you to engage in meaningful discussions during the interview.
✨Tip Number 2
Highlight any relevant experience you have with advanced techniques like CRISPR/Cas9 gene editing or high-resolution microscopy. Being able to discuss your hands-on experience with these methods can set you apart from other candidates.
✨Tip Number 3
Show your enthusiasm for working in a collaborative environment. Be prepared to share examples of how you've successfully worked in teams in the past, as this position emphasizes teamwork alongside independent research.
✨Tip Number 4
Prepare to discuss your long-term career goals and how they align with the objectives of the research project. This shows that you are not only interested in the position but also in contributing to the field of regenerative medicine.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: a PhD student (m/f/d)
Tipps für deine Bewerbung 🫡
Understand the Research Focus: Familiarize yourself with the specific research areas mentioned in the job description, particularly the role of SMYD1 in cardiomyocyte regeneration. This will help you tailor your application to demonstrate your relevant knowledge and interest.
Highlight Relevant Experience: Make sure to emphasize any experience you have in molecular and cellular biology, especially if it relates to techniques like CRISPR/Cas9 gene editing or working with iPSC-derived cardiomyocytes. This will show that you are well-prepared for the position.
Craft a Strong Motivation Letter: In your motivation letter, express your enthusiasm for the project and how your background aligns with the goals of the lab. Discuss your career aspirations and how this PhD position fits into your long-term plans.
Proofread Your Application: Before submitting, carefully proofread your CV and motivation letter to ensure there are no grammatical errors or typos. Clear and professional communication is key, especially since excellent communication skills are required for this role.
Wie du dich auf ein Vorstellungsgespräch bei Universitätsklinikum Ulm vorbereitest
✨Understand the Research Focus
Make sure you have a solid grasp of the research project, especially the role of SMYD1 in cardiomyocyte regeneration. Familiarize yourself with recent findings and be prepared to discuss how your background aligns with these topics.
✨Showcase Your Technical Skills
Highlight any experience you have with advanced techniques mentioned in the job description, such as CRISPR/Cas9 gene editing or high-resolution microscopy. Be ready to provide examples of how you've applied these methods in your previous work.
✨Demonstrate Teamwork and Independence
The position requires both collaborative and independent work. Prepare examples from your past experiences that showcase your ability to work effectively in a team while also being self-motivated and capable of managing your own projects.
✨Prepare for Scientific Communication
Since excellent communication skills are essential, practice explaining complex scientific concepts clearly and concisely. You might be asked to present your previous research, so be ready to discuss it in a way that is engaging and understandable.
