PhD Position (m/f/d) CRISPR 2.0-Enginneering of CAR-T Cells In Vivo in Würzburg

PhD Position (m/f/d)

CRISPR 2.0-Enginneering of CAR-T Cells In Vivo

Universitätsklinikum Würzburg

01.01.2027

Vollzeit

befristet

Application deadline: 31/10/2026

Join an ambitious ERC-funded research project at the interface of genome engineering, immunology, and cell therapy.

The research group is developing next-generation genome-engineering technologies with the goal of enabling the direct generation of therapeutic CAR-T cells inside the human body. This PhD project addresses a highly innovative translational challenge with the potential to advance the future of cancer immunotherapy.

The position offers the opportunity to contribute to pioneering research while gaining expertise across several rapidly evolving fields within a highly collaborative and international scientific environment.

During your PhD, you will gain hands‑on experience in:

• CRISPR 2.0 and next‑generation genome engineering
• CAR‑T cell and immune‑cell engineering
• In vivo cell engineering and targeted delivery technologies
• Synthetic immunology
• Molecular and cellular biology
• Advanced functional characterization of engineered T cells
• Translational cancer research

Ihr Aufgabengebiet

• CRISPR 2.0 genome‑engineering strategies for human T cells
• direct generation of CAR‑T cells in vivo
• viral and non‑viral delivery strategies for genome‑editing components
• molecular, cellular, and functional assays to characterize engineered CAR‑T cells
• efficacy, specificity, and safety of novel genome‑engineering approaches
• contribute your own ideas to an ambitious ERC‑funded research project at the interface of genome editing, immunology, and cell therapy

Ihr Profil

We are looking for an enthusiastic and curious scientist with a strong interest in genome engineering, lipid nanoparticles, and cell therapy.

• A Master's degree or equivalent in molecular biology, biomedicine, biotechnology, biochemistry, immunology, or a related field
• A strong interest in CRISPR technologies, genome engineering, and/or CAR‑T cell biology
• Experience with molecular and cellular biology techniques
• Motivation to learn new technologies and work across disciplinary boundaries
• A collaborative mindset and enthusiasm for ambitious, technology‑driven research
• Good communication skills in English

Previous experience with genome editing, primary T‑cell culture, flow cytometry, viral or non‑viral delivery technologies, or CAR‑T cells is advantageous but not required. More important to us are scientific curiosity, motivation, and the willingness to learn.

Darauf können Sie sich freuen

• Anspruchsvolles, vielfältiges und entwicklungsfähiges Aufgabengebiet
• Attraktive Bezahlung nach TV‑L inkl. Jahressonderzahlung
• Aus- und Weiterbildung in der eigenen Akademie
• Betriebliche Altersvorsorge
• Betriebskindertagesstätte mit verlängerten Öffnungszeiten
• Betriebssportangebote
• Flexible Arbeitszeiten dank Gleitzeitregelung
• Jobrad
• Mitarbeiter Angebote

Dr. Karl Petri

Emmy Noether Gruppenleiter

Tel: +49931 201 44817

Bei einem Hochschulabschluss aus einem Nicht‑EU‑Land wird eine Langfassung der Zeugnisbewertung von der Zentralstelle für Ausländisches Bildungswesen benötigt.

Die Vergütung erfolgt nach den einschlägigen Tarifverträgen. Schwerbehinderte Bewerber/-innen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt eingestellt.

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