PhD Position in Molecular Mechanisms of Human Infertility (m/f/d)

Overview

Infertility affects millions worldwide, yet in many cases the genetic basis remains unknown. Instead of focusing solely on gene-by-gene sequencing, this PhD project aims to uncover the shared molecular mechanisms that drive infertility and open the way for new diagnostics and therapies. Our recent findings show that infertile individuals share phenotypes associated with genotoxic stress and altered androgen receptor (AR) expression . In this PhD project, you will investigate how the cGAS–STING signaling pathway translates genome instability into pathological changes in gonadal tissues. You will study its role in autophagy regulation, innate immune responses, telomere maintenance, and its interaction with AR signaling in the context of reproductive health.

Responsibilities

• You will cover the entire spectrum of wet lab experimental work with the “state of the art” technics
• DNA, RNA, Protein work: isolation and analysis with PCR, qPCR, Western blot; Immunofluorescence, microscopy, histology
• Cell culture; develop new methods like gonadal organoids or work with primary patient’s cells
• Specific data entry, documentation, and archiving work

Qualifications

• Successfully completed a Master’s degree in Cell Biology, Developmental Biology, Genetics or Molecular Biology
• Experience with cell culture and wet lab techniques, including DNA/RNA/protein analyses
• Good command of the English language
• Strong teamwork skills, reliability, and flexibility
• High level of commitment and independent work
• IT skills

We offer

• Goal-oriented, individual training and development opportunities
• Working with the latest techniques / technical equipment
• Flexible working hours within the framework of flexitime
• Possibility of doctorate
• Possibility to publish scientifically is offered and supported
• Regular team meetings
• Collectively agreed remuneration (TV-L E13), attractive company pension scheme (VBL)
• 30 days vacation
• Sustainable travel: job ticket
• Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
• Wide range of health, prevention and sports offers

Contact & Application

For further information please contact Dr. Maria Krivega via e-mail.

Interested? Applications will be accepted until via e-mail or online.

Klinik für Gynäkologische Endokrinologie und Fertilitätsstörungen

Dr. Maria Krivega – group leader

Im Neuenheimer Feld 440

69120 Heidelberg

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