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- Aufgaben: Join our research team to explore X chromosome inactivation using cutting-edge nanopore sequencing.
- Arbeitgeber: Be part of the Medical Genetic Center in Munich, a leader in epigenetics and genomics research.
- Mitarbeitervorteile: Gain hands-on experience in a dynamic lab environment with opportunities for impactful research.
- Warum dieser Job: Contribute to groundbreaking studies that could change the understanding of genetic disorders and their treatments.
- Gewünschte Qualifikationen: Pursuing a Master's in molecular genetics or related fields; hands-on molecular biology experience preferred.
- Andere Informationen: Fluency in German and English is required; this role offers a chance to make a real difference.
External Master Thesis
At the Medical genetic center in Munich (MGZ) 18.09.2023
We are seeking an enthusiastic master's student to join our research team in the field of epigenetics and genomics. In this project, you will explore X chromosome inactivation (XCI) using nanopore sequencing. X-linked genetic disorders affect females less severely due to their second X chromosome, but variable phenotypic expression is influenced by XCI, particularly skewed XCI, impacting disease severity. Accurate measurement of skewed XCI is crucial for predicting disease susceptibility when preventative treatment is available. In this project, we aim to quantify sequence variants and methylation patterns in order to characterize the X chromosome disease variant and skew and its directionality in patients. Additionally, you will be involved in developing a protocol for multiplexing nanopore Cas9-enriched sequencing runs, which promises to streamline genomic studies. This part of the project will have a broader impact on the genomics community, offering a more efficient and cost-effective approach to sequencing.
Your tasks
- DNA extraction and preparation of nanopore sequencing libraries
- Optimization of nanopore Cas9-enrichment multiplexing and adaptive sampling protocols
- Documentation of experiments
- Assist with long read sequencing data analysis
Your profile
- Pursuing a Masters in molecular genetics, biology, biomedicine, biochemistry, or a relevant field
- Hands-on experience in molecular biology (DNA extraction and DNA library preparation preferred)
- Theoretical knowledge of genetics (genome structure, modes of inheritance)
- Working knowledge of sequencing data processing and analysis methodology (mapping, data visualization, interpretation)
- Experience in sequencing data analysis is a plus but not required
- Fluent in German and English
For further information about the ab and the advertisement please follow the link.
External Master Thesis Arbeitgeber: Xci
Kontaktperson:
Xci HR Team
StudySmarter Bewerbungstipps 🤫
So bekommst du den Job: External Master Thesis
✨Tip Number 1
Make sure to familiarize yourself with the latest research in epigenetics and genomics, especially regarding X chromosome inactivation. This will not only help you understand the project better but also show your genuine interest during discussions.
✨Tip Number 2
If you have any hands-on experience with nanopore sequencing or similar technologies, be ready to discuss specific projects or experiments you've worked on. Highlighting practical skills can set you apart from other candidates.
✨Tip Number 3
Networking is key! Reach out to current or former students who have completed their thesis at the Medical Genetic Center. They can provide valuable insights into the team dynamics and expectations.
✨Tip Number 4
Prepare to discuss your understanding of sequencing data processing and analysis methodologies. Even if you lack extensive experience, showing that you are eager to learn and adapt can make a strong impression.
Diese Fähigkeiten machen dich zur top Bewerber*in für die Stelle: External Master Thesis
Tipps für deine Bewerbung 🫡
Understand the Project: Make sure to thoroughly read the job description and understand the specifics of the project. Familiarize yourself with terms like X chromosome inactivation, nanopore sequencing, and the significance of skewed XCI.
Tailor Your CV: Highlight your relevant experience in molecular biology, especially any hands-on work with DNA extraction and library preparation. Make sure to include any coursework or projects related to genetics and genomics.
Craft a Strong Cover Letter: In your cover letter, express your enthusiasm for the research area and explain why you are a good fit for the project. Mention your theoretical knowledge of genetics and any relevant skills in sequencing data analysis.
Language Proficiency: Since fluency in both German and English is required, ensure that your application reflects your language skills. If applicable, mention any experiences where you used these languages in an academic or professional setting.
Wie du dich auf ein Vorstellungsgespräch bei Xci vorbereitest
✨Show Your Passion for Epigenetics
Make sure to express your enthusiasm for the field of epigenetics and genomics during the interview. Share any relevant projects or coursework that sparked your interest, and be prepared to discuss how this master's thesis aligns with your career goals.
✨Demonstrate Your Technical Skills
Highlight your hands-on experience in molecular biology, especially DNA extraction and library preparation. Be ready to discuss specific techniques you've used and any challenges you faced, as well as how you overcame them.
✨Prepare for Data Analysis Questions
Since the role involves long read sequencing data analysis, brush up on your knowledge of sequencing data processing and analysis methodologies. Be prepared to explain how you would approach mapping, data visualization, and interpretation of sequencing data.
✨Communicate Effectively in Both Languages
Fluency in both German and English is essential for this position. Practice discussing your research and technical skills in both languages to ensure you can communicate effectively with the interviewers.
